Gene

traf6

ID

ZDB-GENE-030131-5735

Name

TNF receptor-associated factor 6

Symbol

traf6 Nomenclature History

Previous Names

fi15f02
wu:fi15f02
zgc:63704

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have tumor necrosis factor receptor binding activity and ubiquitin-protein transferase activity. Involved in several processes, including innate immune response; neutrophil chemotaxis; and response to virus. Predicted to localize to cytoplasm. Is expressed in central nervous system; gill; heart; immune system; and liver. Orthologous to human TRAF6 (TNF receptor associated factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63704 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Aripaka et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With traf6 Human Ortholog

No data available

Associated With traf6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001293	Zinc finger, TRAF-type
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR002083	MATH/TRAF domain
Domain	IPR018957	Zinc finger, C3HC4 RING-type
Domain	IPR027139	TNF receptor-associated factor 6, C3HC3D-type RING zinc finger
Domain	IPR037309	TNF receptor-associated factor 6, MATH domain
Domain	IPR049342	TRAF1-6, MATH domain
Family	IPR012227	TNF receptor-associated factor TRAF, metazoa
Homologous_superfamily	IPR008974	TRAF-like
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Length	MATH/TRAF domain	TNF receptor-associated factor 6, C3HC3D-type RING zinc finger	TNF receptor-associated factor 6, MATH domain	TNF receptor-associated factor TRAF, metazoa	TRAF1-6, MATH domain	TRAF-like	Zinc finger, C3HC4 RING-type	Zinc finger, RING/FYVE/PHD-type	Zinc finger, RING-type	Zinc finger, RING-type, conserved site	Zinc finger, TRAF-type
UniProtKB:Q6IWL4 InterPro PDB	542

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	traf6-201 (1) Ensembl	Ensembl	4,707 nt	Select Tool
mRNA	traf6-202 (1) Ensembl	Ensembl	1,939 nt	Select Tool ZFIN BLAST
mRNA	traf6-203 (1) Ensembl	Ensembl	1,653 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-traf6		traf6			WB		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations