ZFIN ID: ZDB-GENE-030131-5735
Gene Name: TNF receptor-associated factor 6
Gene Symbol: traf6    Nomenclature History

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Previous Names: fi15f02, wu:fi15f02, zgc:63704

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have tumor necrosis factor receptor binding activity and ubiquitin-protein transferase activity. Involved in several processes, including innate immune response; neutrophil chemotaxis; and response to virus. Predicted to localize to plasma membrane signaling receptor complex. Is expressed in central nervous system; gill; heart; immune system; and liver. Orthologous to human TRAF6 (TNF receptor associated factor 6).
Genome Resources: Alliance (1),  Gene:554561 (1),  Ensembl(GRCz11):ENSDARG00000028058 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63704]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa151 Point Mutation Unknown Premature Stop ENU
sa244 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-traf6
1
MO1-traf6 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH traf6 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH traf6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of transcription, DNA-templated (more)
Cellular Component cytoplasm (more)
Molecular Function ubiquitin-protein transferase activity (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA traf6-201 (1)    Ensembl 4707
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM traf6 No data available
MARKER RELATIONSHIPS
traf6 Contained in: [BAC] DKEY-56P7 (1) (order this)
traf6 Encodes: [EST] fi15f02
[cDNA] MGC:63704 (1), MGC:198210 (1), MGC:198214 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001044752 (1) 1733 nt
Genomic GenBank:AL929208 (1) 189608 nt
Select Tool
Polypeptide UniProtKB:Q6IWL4 (1) 542 aa
Sequence Information (all 23)
ORTHOLOGY for traf6 ( Chr: 7 )
CITATIONS (49)