Gene
taf1
- ID
- ZDB-GENE-030131-5576
- Name
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
- Symbol
- taf1 Nomenclature History
- Previous Names
-
- wu:fi04f03
- wu:fy39f07
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II general transcription initiation factor activity and TBP-class protein binding activity. Acts upstream of or within developmental growth and midbrain development. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to human TAF1 (TATA-box binding protein associated factor 1) and TAF1L (TATA-box binding protein associated factor 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6898986 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| X-linked dystonia-parkinsonism | Alliance | Dystonia-Parkinsonism, X-linked | 314250 |
| Intellectual developmental disorder, X-linked syndromic 33 | 300966 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR009067 | TAFII-230 TBP-binding |
| Domain | IPR022591 | Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain |
| Domain | IPR041670 | Zinc knuckle |
| Family | IPR011177 | Transcription initiation factor TFIID subunit 1, animal |
| Family | IPR040240 | Transcription initiation factor TFIID subunit 1 |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036741 | TAFII-230 TBP-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | TAFII-230 TBP-binding | TAFII-230 TBP-binding domain superfamily | Transcription initiation factor TFIID subunit 1 | Transcription initiation factor TFIID subunit 1, animal | Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain | Zinc knuckle |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QDY7
|
1982 | |||||||||
|
UniProtKB:A0A8M9Q8M9
|
1971 | |||||||||
|
UniProtKB:A0A8M9Q3C1
|
1984 | |||||||||
|
UniProtKB:Q1LYC2
|
1947 | |||||||||
|
UniProtKB:A0A8M2BCS6
|
1949 |
Interactions and Pathways
No data available
Plasmids
No data available