Gene

fxr1

ID
ZDB-GENE-030131-5431
Name
FMR1 autosomal homolog 1
Symbol
fxr1 Nomenclature History
Previous Names
  • wu:fb16f11
  • wu:fd18c10
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have mRNA 3'-UTR binding activity; protein homodimerization activity; and translation regulator activity. Involved in animal organ development; muscle fiber development; and somitogenesis. Predicted to localize to several cellular components, including dendrite; polysome; and postsynaptic density. Is expressed in several structures, including adaxial cell; heart; musculature system; neurons; and skeletal muscle myoblast. Orthologous to human FXR1 (FMR1 autosomal homolog 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fxr1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital myopathy 9A Alliance ?Congenital myopathy 9A with respiratory insufficiency and bone fractures 618822
congenital myopathy 9B Alliance Congenital myopathy 9B, proximal, with minicore lesions 618823
Associated With fxr1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004087 K Homology domain
Domain IPR004088 K Homology domain, type 1
Domain IPR008395 Agenet-like domain
Domain IPR022034 Fragile X messenger ribonucleoprotein 1-like, C-terminal core
Domain IPR032172 Fragile X-related protein 1, C-terminal region 1
Domain IPR032177 Fragile X-related 1 protein, C-terminal region 3
Domain IPR040472 Synaptic functional regulator FMRP, KH0 domain
Domain IPR041560 FMR1, tudor domain
Domain IPR047425 RNA-binding protein FXR1, first Tudor-like Agenet domain
Domain IPR047427 RNA-binding protein FXR1, second Tudor-like Agenet domain
Domain IPR047494 RNA-binding protein FXR1, first type I K homology domain
Domain IPR047495 RNA-binding protein FXR1, second type I K homology domain
Domain IPR047496 RNA-binding protein FXR2, third type I K homology domain
Family IPR040148 Fragile X messenger ribonucleoprotein 1
Homologous_superfamily IPR036612 K Homology domain, type 1 superfamily
Domain Details Per Protein
Protein Length Agenet-like domain FMR1, tudor domain Fragile X messenger ribonucleoprotein 1 Fragile X messenger ribonucleoprotein 1-like, C-terminal core Fragile X-related 1 protein, C-terminal region 3 Fragile X-related protein 1, C-terminal region 1 K Homology domain K Homology domain, type 1 K Homology domain, type 1 superfamily RNA-binding protein FXR1, first Tudor-like Agenet domain RNA-binding protein FXR1, first type I K homology domain RNA-binding protein FXR1, second Tudor-like Agenet domain RNA-binding protein FXR1, second type I K homology domain RNA-binding protein FXR2, third type I K homology domain Synaptic functional regulator FMRP, KH0 domain
UniProtKB:A0A9F7TY55 648
UniProtKB:F1QLR3 622
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fxr1 polyclonal Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations