ZFIN ID: ZDB-GENE-030131-5431
Gene Name: fragile X mental retardation, autosomal homolog 1
Gene Symbol: fxr1    Nomenclature History

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Previous Names: wu:fb16f11, wu:fd18c10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have mRNA 3'-UTR binding activity; protein homodimerization activity; and translation regulator activity. Involved in animal organ development; muscle fiber development; and somitogenesis. Predicted to localize to several cellular components, including dendrite; polysome; and postsynaptic density. Is expressed in several structures, including adaxial cell; heart; musculature system; neurons; and skeletal muscle myoblast. Orthologous to human FXR1 (FMR1 autosomal homolog 1).
Genome Resources: Alliance (1),  Gene:327220 (1),  Ensembl(GRCz11):ENSDARG00000022968 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a270 Complex Unknown Unknown CRISPR
la022366Tg Transgenic Insertion Unknown Unknown DNA
la022367Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022368Tg Transgenic Insertion Unknown Unknown DNA
    sa24219 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24220 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fxr1 1
    CRISPR2-fxr1 1
    CRISPR3-fxr1 1
    CRISPR4-fxr1 1
    MO1-fxr1 N/A 1
    MO2-fxr1 N/A 1
    MO3-fxr1 N/A 1
    MO4-fxr1 N/A 1
    MO5-fxr1 N/A 1
    DISEASE ASSOCIATED WITH fxr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Myopathy, congenital proximal, with minicore lesions 618823
    ?Myopathy, congenital, with respiratory insufficiency and bone fractures 618822
    DISEASE ASSOCIATED WITH fxr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart development (more)
    Cellular Component axon (more)
    Molecular Function mRNA binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fxr1-201 (1)    Ensembl 2737
    fxr1-203 (1)    Ensembl 2753
    ncRNA fxr1-004 (1)    Ensembl 669
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-fxr1 polyclonal Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fxr1 No data available
    MARKER RELATIONSHIPS
    fxr1 Contained in: [BAC] CH73-312P9 (1)
    fxr1 Encodes: [EST] eu176 (1), fb16f11 (1), fd18c10
    [cDNA] MGC:66226 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201301 (1) 2724 nt
    Genomic GenBank:CU468728 (1) 95874 nt
    Select Tool
    Polypeptide UniProtKB:Q6NUW6 (1) 646 aa
    Sequence Information (all 26)
    ORTHOLOGY for fxr1 ( Chr: 22 )
    CITATIONS (40)