Gene
gclc
- ID
- ZDB-GENE-030131-5056
- Name
- glutamate-cysteine ligase, catalytic subunit
- Symbol
- gclc Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable anion binding activity; glutamate-cysteine ligase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including alpha-amino acid metabolic process; cell redox homeostasis; and glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Is expressed in several structures, including alar plate midbrain region; gut; intermediate cell mass of mesoderm; midbrain; and sensory system. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1049 (8 images)
- IMAGE:7153748 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018448Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018450Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35401 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 7 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 7 | 230450 |
| {Myocardial infarction, susceptibility to} | 608446 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamate-cysteine ligase catalytic subunit | Glutamine synthetase/guanido kinase, catalytic domain |
|---|---|---|---|---|
| UniProtKB:Q6NV35 | InterPro | 631 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-71K24 | ZFIN Curated Data | |
| Encodes | EST | cb1049 | Thisse et al., 2001 | |
| Encodes | EST | fe36e11 | ||
| Encodes | EST | IMAGE:7153748 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:55305 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:85625 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191729 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199277 (1) | 3186 nt | ||
| Genomic | GenBank:CR376766 (2) | 155126 nt | ||
| Polypeptide | UniProtKB:Q6NV35 (1) | 631 aa |
- Subba, R., Fasciolo, G., Geremia, E., Muscari Tomajoli, M.T., Petito, A., Carrella, S., Mondal, A.C., Napolitano, G., Venditti, P. (2024) Simultaneous induction of systemic hyperglycaemia and stress impairs brain redox homeostasis in the adult zebrafish. Archives of biochemistry and biophysics. 759:110101
- Ajouaou, Y., Magnani, E., Madakashira, B., Jenkins, E., Sadler, K.C. (2023) atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers. Cancers. 15(8):
- Badenetti, L., Manzoli, R., Rubin, M., Cozza, G., Moro, E. (2023) Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System. International Journal of Molecular Sciences. 24(7):
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Xu, F.H., Qiu, Y.Z., Zhang, Y., Yang, F.H., Ji, M.M., Liu, K.C., Jin, M., Zhang, S.S., Li, B. (2023) The molecular mechanism of three novel peptides from C-phycocyanin alleviates MPTP-induced Parkinson's disease-like pathology in zebrafish. Food & function. 14(13):6157-6171
- Xu, Y., Peng, T., Zhou, Q., Zhu, J., Liao, G., Zou, F., Meng, X. (2023) Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 266:109550
- Chen, C., He, M., Li, X., Yu, L., Liu, Y., Yang, Y., Li, L., Jia, J., Li, B. (2022) H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish. Life (Basel, Switzerland). 12(9)
- Dixon, S.C., Calder, B.J., Lilya, S.M., Davies, B.M., Martin, A., Peterson, M., Hansen, J.M., Suli, A. (2022) Valproic acid affects neurogenesis during early optic tectum development in zebrafish. Biology Open. 12(1):
- Lasbleiz, C., Peyrel, A., Tarot, P., Sarniguet, J., Crouzier, L., Cubedo, N., Delprat, B., Rossel, M., Maurice, T., Liévens, J.C. (2022) Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling. Redox Biology. 58:102542102542
- Üstündağ, F.D., Ünal, İ., Üstündağ, Ü.V., Cansız, D., Beler, M., Karagöz, A., Kara Subaşat, H., Alturfan, A.A., Mega Tiber, P., Emekli-Alturfan, E. (2022) 3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos. Neurochemical research. 47(6):1553-1564
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