Gene

mark2a

ID

ZDB-GENE-030131-4145

Name

MAP/microtubule affinity-regulating kinase 2a

Symbol

mark2a Nomenclature History

Previous Names

fc75f05
si:dkey-175m17.8
wu:fc75f05 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to localize to cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mark2a Human Ortholog

No data available

Associated With mark2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001772	Kinase associated domain 1 (KA1)
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR049508	Serine/threonine-protein kinase MARK 1-4, catalytic domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR028375	KA1 domain/Ssp2, C-terminal

Domain Details Per Protein

Protein	Length	KA1 domain/Ssp2, C-terminal	Kinase associated domain 1 (KA1)	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase MARK 1-4, catalytic domain	Ubiquitin-associated domain
UniProtKB:A0A8M3AU19 InterPro	772
UniProtKB:A0A8M3ALM5 InterPro	769
UniProtKB:A0A8M3B4V1 InterPro	782
UniProtKB:A0A8M2B8C0 InterPro	781
UniProtKB:A0A8M2B8F7 InterPro	770
UniProtKB:A0A8M3B4V9 InterPro	723
UniProtKB:A0A8M2B8K8 InterPro	769
UniProtKB:E9QHU0 InterPro	736
UniProtKB:A0A8M3AU26 InterPro	723
UniProtKB:A0A8M3B4V5 InterPro	760
UniProtKB:A0A8M3AMC2 InterPro	781
UniProtKB:A0A8M3ALN0 InterPro	760
UniProtKB:A0A8M9PDA8 InterPro	654
UniProtKB:A0A8M3AX04 InterPro	773
UniProtKB:A0A8M3AMD0 InterPro	753

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	mark2a-207 (1) Ensembl	Ensembl	854 nt	Select Tool ZFIN BLAST
mRNA	mark2a-201 (1) Ensembl	Ensembl	2,280 nt	Select Tool ZFIN BLAST
mRNA	mark2a-203 (1) Ensembl	Ensembl	455 nt	Select Tool ZFIN BLAST
mRNA	mark2a-204 (1) Ensembl	Ensembl	726 nt	Select Tool ZFIN BLAST
mRNA	mark2a-205 (1) Ensembl	Ensembl	3,084 nt	Select Tool ZFIN BLAST
mRNA	mark2a-206 (1) Ensembl	Ensembl	419 nt	Select Tool ZFIN BLAST
mRNA	mark2a-208 (1) Ensembl	Ensembl	2,271 nt	Select Tool ZFIN BLAST
ncRNA	mark2a-006 (1) Ensembl	Ensembl	841 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations