Gene
ptena
- ID
- ZDB-GENE-030131-3776
- Name
- phosphatase and tensin homolog A
- Symbol
- ptena Nomenclature History
- Previous Names
-
- wu:fc52g04
- zgc:73086
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Exhibits lipid phosphatase activity. Involved in several processes, including lifelong otolith mineralization; phosphatidylinositol dephosphorylation; and regulation of protein kinase B signaling. Predicted to localize to PML body and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; presumptive neural retina; and ventral wall of dorsal aorta. Orthologous to human PTEN (phosphatase and tensin homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73086 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bannayan-Riley-Ruvalcaba syndrome | Alliance | Cowden syndrome 1 | 158350 |
| Bannayan-Riley-Ruvalcaba syndrome | Alliance | Lhermitte-Duclos disease | 158350 |
| macrocephaly-autism syndrome | Alliance | Macrocephaly/autism syndrome | 605309 |
| prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
| {Glioma susceptibility 2} | 613028 | ||
| {Meningioma} | 607174 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR014020 | Tensin phosphatase, C2 domain |
| Domain | IPR029023 | Tensin-type phosphatase domain |
| Domain | IPR045101 | PTEN, phosphatase domain |
| Family | IPR017361 | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN |
| Family | IPR051281 | Dual-specificity lipid and protein phosphatase |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN | C2 domain superfamily | Dual-specificity lipid and protein phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTEN, phosphatase domain | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6TGR7
|
431 | ||||||||||
|
UniProtKB:A0A8M1PHN1
|
454 | ||||||||||
|
UniProtKB:Q6PC66
|
452 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptena | monoclonal | IgG | Rabbit |
|
Cell Signaling Technology, Inc.
|
9 |
Plasmids
No data available