ZFIN ID: ZDB-GENE-030131-3776
Gene Name: phosphatase and tensin homolog A
Gene Symbol: ptena    Nomenclature History

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Previous Names: wu:fc52g04, zgc:73086

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits lipid phosphatase activity. Involved in several processes, including lifelong otolith mineralization; phosphatidylinositol dephosphorylation; and regulation of protein kinase B signaling. Predicted to localize to several cellular components, including cell projection; cytosol; and nucleus. Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; presumptive neural retina; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources: Alliance (1),  Gene:794088 (1),  Ensembl(GRCz11):ENSDARG00000071018 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1864 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la013071Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12727 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39161 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42927 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ptena
    1
    MO1-ptena N/A 4
    MO2-ptena N/A 1
    MO3-ptena N/A 2
    DISEASE ASSOCIATED WITH ptena HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
    Lhermitte-Duclos syndrome 158350
    macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
    prostate cancer Alliance Prostate cancer, somatic 176807
    {Glioma susceptibility 2} 613028
    {Meningioma} 607174
    DISEASE ASSOCIATED WITH ptena VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphatidylinositol dephosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function lipid phosphatase activity (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ptena-202 (1)    Ensembl 1341
    ptena-203 (1)    Ensembl 2993
    ncRNA ptena-003 (1)    Ensembl 658
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ptena monoclonal IgG Rabbit IHC, WB Cell Signaling Technology, Inc.
    6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ptena No data available
    MARKER RELATIONSHIPS
    ptena Contained in: [BAC] CH211-243K10 (1)
    ptena Encodes: [EST] fc52g04
    [cDNA] MGC:73086 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200708 (1) 1646 nt
    Genomic GenBank:CR384057 (1) 154493 nt
    Select Tool
    Polypeptide UniProtKB:E7FC59 (1) 467 aa
    Sequence Information (all 25)
    ORTHOLOGY for ptena ( Chr: 17 )
    CITATIONS (56)