Gene

mtor

ID

ZDB-GENE-030131-2974

Name

mechanistic target of rapamycin kinase

Symbol

mtor Nomenclature History

Previous Names

ztor (1)
frap1
wu:fc22h08

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Involved in several processes, including positive regulation of myelination; regulation of TOR signaling; and skin development. Predicted to localize to TORC1 complex; TORC2 complex; and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Is expressed in several structures, including digestive system; male organism; myotome; nervous system; and somite. Orthologous to human MTOR (mechanistic target of rapamycin kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144752 (4 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtor Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Focal cortical dysplasia, type II, somatic	607341
		Smith-Kingsmore syndrome	616638

Associated With mtor Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR003151	PIK-related kinase, FAT
Domain	IPR003152	FATC domain
Domain	IPR009076	FKBP12-rapamycin binding domain
Domain	IPR014009	PIK-related kinase
Domain	IPR024585	Serine/threonine-protein kinase mTOR domain
Domain	IPR026683	Serine/threonine-protein kinase TOR, catalytic domain
Family	IPR050517	DNA Damage Response and Repair Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR036738	FKBP12-rapamycin binding domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily