ZFIN ID: ZDB-GENE-030131-2974
Gene Name: mechanistic target of rapamycin kinase
Gene Symbol: mtor    Nomenclature History

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Previous Names: ztor (1), frap1, wu:fc22h08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in several processes, including positive regulation of myelination; regulation of TOR signaling; and skin development. Predicted to localize to TORC1 complex; TORC2 complex; and nucleus. Is expressed in several structures, including digestive system; male organism; myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
Genome Resources: Alliance (1),  Gene:324254 (1),  Ensembl(GRCz11):ENSDARG00000053196 (2)
GENE EXPRESSION
All Expression Data: 18 figures from 12 publications
Directly Submitted Expression Data: 5 figures (4 images) from Thisse et al., 2004 [IMAGE:7144752]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016408Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11792 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16755 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21374 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30906 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31678 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34485 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38710 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41292 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • xu015Gt Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mtor N/A 7
    MO2-mtor N/A 1
    DISEASE ASSOCIATED WITH mtor HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Focal cortical dysplasia, type II, somatic 607341
    Smith-Kingsmore syndrome 616638
    DISEASE ASSOCIATED WITH mtor VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of myelination (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mtor-202 (1)    Ensembl 8700
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-mtor polyclonal IgG Rabbit IHC GeneTex
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mtor No data available
    MARKER RELATIONSHIPS
    mtor Contained in: [BAC] CH211-95C6 (1), CH211-119D14 (1), CH211-220J14 (1), DKEY-75A21 (1) (order this)
    mtor Encodes: [EST] fc22h08, IMAGE:7144752 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077211 (1) 8467 nt
    Genomic GenBank:CR354402 (1) 169701 nt
    Select Tool
    Polypeptide UniProtKB:B0UX67 (1) 2563 aa
    Sequence Information (all 25)
    ORTHOLOGY for mtor ( Chr: 8 )
    CITATIONS (69)