Gene

mtor

ID
ZDB-GENE-030131-2974
Name
mechanistic target of rapamycin kinase
Symbol
mtor Nomenclature History
Previous Names
  • ztor (1)
  • frap1
  • wu:fc22h08
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in several processes, including positive regulation of myelination; regulation of TOR signaling; and skin development. Predicted to localize to TORC1 complex; TORC2 complex; and nucleus. Is expressed in several structures, including digestive system; male organism; myotome; nervous system; and somite. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mtor Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Focal cortical dysplasia, type II, somatic 607341
Smith-Kingsmore syndrome 616638
Associated With mtor Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR003151 PIK-related kinase, FAT
Domain IPR003152 FATC domain
Domain IPR009076 FKBP12-rapamycin binding domain
Domain IPR014009 PIK-related kinase
Domain IPR024585 Domain of unknown function DUF3385, target of rapamycin protein
Family IPR026683 Serine/threonine-protein kinase TOR
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR036738 FKBP12-rapamycin binding domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold Domain of unknown function DUF3385, target of rapamycin protein FATC domain FKBP12-rapamycin binding domain FKBP12-rapamycin binding domain superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site PIK-related kinase PIK-related kinase, FAT Protein kinase-like domain superfamily Serine/threonine-protein kinase TOR
UniProtKB:A1IMA9 2515
UniProtKB:Q58EJ0 369
UniProtKB:Q568M6 414
UniProtKB:F1Q9H9 2515
UniProtKB:B0UX67 2563
UniProtKB:Q06RG6 2515
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-mtor polyclonal IgG Rabbit
  • IHC
GeneTex
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations