Gene

brd4

ID

ZDB-GENE-030131-267

Name

bromodomain containing 4

Symbol

brd4 Nomenclature History

Previous Names

fb18g03
wu:fb18g03 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables chromatin binding activity and histone binding activity. Acts upstream of or within thrombocyte differentiation. Located in condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Toyama et al., 2008

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Bielczyk-Maczy?ska et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With brd4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 6	Alliance	Cornelia de Lange syndrome 6	620568

Associated With brd4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018359	Bromodomain, conserved site
Domain	IPR001487	Bromodomain
Domain	IPR027353	NET domain
Domain	IPR031354	Bromodomain protein 4, C-terminal
Domain	IPR043508	Brdt, bromodomain, repeat I
Domain	IPR043509	Brdt, bromodomain, repeat II
Family	IPR050935	Bromodomain-containing chromatin reader
Homologous_superfamily	IPR036427	Bromodomain-like superfamily
Homologous_superfamily	IPR038336	NET domain superfamily