ZFIN ID: ZDB-GENE-030131-267
Gene Name: bromodomain containing 4
Gene Symbol: brd4    Nomenclature History

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Previous Names: fb18g03, wu:fb18g03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits chromatin binding activity and histone binding activity. Involved in thrombocyte differentiation. Localizes to condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4).
Genome Resources: Alliance (1),  Gene:570531 (1),  Ensembl(GRCz11):ENSDARG00000078904 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015264Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024293Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa855 Point Mutation Unknown Premature Stop ENU
    sa8905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33315 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-brd4 N/A 1
    MO2-brd4 N/A 1
    PHENOTYPE
    Data: Fig. S22 from Bielczyk-MaczyƄska et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH brd4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH brd4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process thrombocyte differentiation (more)
    Cellular Component condensed chromosome (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA brd4-202 (1)    Ensembl 6023
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-brd4 polyclonal IgG Rabbit IHC, WB Spring Valley Laboratories, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM brd4 No data available
    MARKER RELATIONSHIPS
    brd4 Contained in: [BAC] CH211-280H11 (1)
    brd4 Encodes: [EST] fb18g03
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001111281 (1) 5400 nt
    Genomic GenBank:AL954361 (1) 161681 nt
    Select Tool
    Polypeptide UniProtKB:A0A140TAU4 (1) 1519 aa
    Sequence Information (all 11)
    ORTHOLOGY for brd4 ( Chr: 3 )
    CITATIONS (28)