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Gene

brd4

ID
ZDB-GENE-030131-267
Name
bromodomain containing 4
Symbol
brd4 Nomenclature History
Previous Names
  • fb18g03
  • wu:fb18g03 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Enables chromatin binding activity and histone binding activity. Acts upstream of or within thrombocyte differentiation. Located in condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in colon cancer and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Toyama et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Bielczyk-MaczyƄska et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brd4 Human Ortholog
No data available
Associated With brd4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR001487 Bromodomain
Domain IPR027353 NET domain
Domain IPR031354 Bromodomain protein 4, C-terminal
Domain IPR043508 Brdt, bromodomain, repeat I
Domain IPR043509 Brdt, bromodomain, repeat II
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR038336 NET domain superfamily
Domain Details Per Protein
Protein Length Brdt, bromodomain, repeat I Brdt, bromodomain, repeat II Bromodomain Bromodomain, conserved site Bromodomain-like superfamily Bromodomain protein 4, C-terminal NET domain NET domain superfamily
UniProtKB:A0A140TAU4 1519
UniProtKB:F1R5H6 1444
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-brd4 polyclonal IgG Rabbit
  • IHC
  • WB
Spring Valley Laboratories, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations