Gene
urb2
- ID
- ZDB-GENE-030131-2621
- Name
- URB2 ribosome biogenesis homolog
- Symbol
- urb2 Nomenclature History
- Previous Names
-
- fc13e02
- si:dkey-162b3.2
- wu:fc13e02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Involved in regulation of signal transduction by p53 class mediator. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in caudal hematopoietic tissue. Orthologous to human URB2 (URB2 ribosome biogenesis homolog).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Cai et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Cai et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal | Ribosome Biogenesis Regulator |
|---|---|---|---|
|
UniProtKB:B0V0U6
|
326 | ||
|
UniProtKB:B0V0U5
|
1495 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:urb2-FLAG) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-162B3 | ZFIN Curated Data | |
| Encodes | EST | fc13e02 | ||
| Encodes | EST | wz11896 | ||
| Has Artifact | cDNA | MGC:136305 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123301 (1) | 5161 nt | ||
| Genomic | GenBank:CR762497 (1) | 258636 nt | ||
| Polypeptide | UniProtKB:B0V0U5 (1) | 1495 aa |
- Huang, W., Yue, Y., Hao, W., Zhang, Z., Cai, P., Yang, D. (2024) mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. 19(9):1277-1288
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- He, J., Chen, J., Wei, X., Leng, H., Mu, H., Cai, P., Luo, L. (2019) mTORC1 Signaling is Required for the Dedifferentiation from Biliary Cell to Bi-potential Progenitor Cell in Zebrafish Liver Regeneration. Hepatology (Baltimore, Md.). 70(6):2092-2106
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Cai, P., Mao, X., Zhao, J., Luo, L. (2018) Ribosome biogenesis protein Urb2 regulates hematopoietic stem cells development via P53 pathway in zebrafish. Biochemical and Biophysical Research Communications. 497(2):776-782
- Sztal, T.E., McKaige, E.A., Williams, C., Ruparelia, A.A., Bryson-Richardson, R.J. (2018) Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein. PLoS Genetics. 14:e1007212
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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