Gene
cltca
- ID
- ZDB-GENE-030131-2299
- Name
- clathrin, heavy chain a (Hc)
- Symbol
- cltca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly; mitotic cell cycle; and receptor-mediated endocytosis. Predicted to localize to clathrin complex; clathrin-coated endocytic vesicle; and spindle. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Is expressed in axial vasculature; blood; intermediate cell mass of mesoderm; notochord; and ventral mesoderm. Orthologous to human CLTC (clathrin heavy chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1033 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 56 | Alliance | Intellectual developmental disorder, autosomal dominant 56 | 617854 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015348 | Clathrin, heavy chain, linker, core motif |
| Family | IPR016341 | Clathrin, heavy chain |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR016025 | Clathrin heavy chain, N-terminal |
| Repeat | IPR000547 | Clathrin, heavy chain/VPS, 7-fold repeat |
| Repeat | IPR022365 | Clathrin, heavy chain, propeller repeat |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | Clathrin, heavy chain | Clathrin, heavy chain, linker, core motif | Clathrin heavy chain, N-terminal | Clathrin, heavy chain, propeller repeat | Clathrin, heavy chain/VPS, 7-fold repeat | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DK43
|
1680 | |||||||
|
UniProtKB:A0A286YAZ4
|
1684 | |||||||
|
UniProtKB:Q6DRI2
|
1680 | |||||||
|
UniProtKB:A0A8M2BJY0
|
1681 | |||||||
|
UniProtKB:A0A8M3AWS2
|
1685 | |||||||
|
UniProtKB:F1R966
|
1680 |
Interactions and Pathways
No data available
Plasmids
No data available