Gene
alcamb
- ID
- ZDB-GENE-030131-1768
- Name
- activated leukocyte cell adhesion molecule b
- Symbol
- alcamb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables identical protein binding activity. Acts upstream of or within axonogenesis involved in innervation; forebrain cell migration; and retinal ganglion cell axon guidance. Located in axon. Is expressed in several structures, including ectoderm; muscle; nervous system; neural plate; and neural rod. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d131 (29 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011450Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la012686Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019203Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019204Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027604Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027605Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12223 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35862 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa42525 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-alcamb | N/A | (2) |
| MO2-alcamb | N/A | Brown et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
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Domain Details Per Protein
| Protein | Length | CD80-like, immunoglobulin C2-set | Cell Surface Receptors and Adhesion Molecules | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin/major histocompatibility complex, conserved site | Immunoglobulin subtype 2 | Immunoglobulin V-set domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B3L9
|
552 | ||||||||||
|
UniProtKB:F1QE54
|
562 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
alcamb-201
(1)
|
Ensembl | 3,078 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-190H2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-229D2 | ZFIN Curated Data | |
| Encodes | EST | fb53h09 | ||
| Encodes | EST | fb80a10 | ||
| Encodes | EST | fc14b01 | ||
| Encodes | cDNA | cssl:d131 | Bushell et al., 2007 | |
| Encodes | cDNA | cssl:d176 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:194978 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195006 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212634 (1) | 3083 nt | ||
| Genomic | GenBank:CR848759 (2) | 167536 nt | ||
| Polypeptide | UniProtKB:F1QE54 (1) | 562 aa |
- Jiang, Z., El-Brolosy, M.A., Serobyan, V., Welker, J.M., Retzer, N., Dooley, C.M., Jakutis, G., Juan, T., Fukuda, N., Maischein, H.M., Balciunas, D., Stainier, D.Y.R. (2022) Parental mutations influence wild-type offspring via transcriptional adaptation. Science advances. 8:eabj2029
- El-Brolosy, M.A., Kontarakis, Z., Rossi, A., Kuenne, C., Günther, S., Fukuda, N., Kikhi, K., Boezio, G.L.M., Takacs, C.M., Lai, S.L., Fukuda, R., Gerri, C., Giraldez, A.J., Stainier, D.Y.R. (2019) Genetic compensation triggered by mutant mRNA degradation. Nature. 568(7751):193-197
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Mayrhofer, M., Gourain, V., Reischl, M., Affaticati, P., Jenett, A., Joly, J.S., Benelli, M., Demichelis, F., Poliani, P.L., Sieger, D., Mione, M. (2017) A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK/PI3K induced malignant growth. Disease models & mechanisms. 10(1):15-28
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hörnberg, H., Cioni, J.M., Harris, W.A., Holt, C.E. (2016) Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:12697-12706
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ren, L., Tan, X.J., Xiong, Y.F., Xu, K., Zhou, Y., Zhong, H., Liu, Y., Hong, Y., Liu, S.J. (2014) Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Gene. 552(2):265-71
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Brown, K.E., Keller, P.J., Ramialison, M., Rembold, M., Stelzer, E.H., Loosli, F., and Wittbrodt, J. (2010) Nlcam modulates midline convergence during anterior neural plate morphogenesis. Developmental Biology. 339(1):14-25
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