Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030116-2
Gene Name: estrogen receptor 2a
Gene Symbol: esr2a
Previous Names: ER[b]2 (1), ER[b]a (1), ERbeta-B (1), NR3A2-B (1), zfER[b]2 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 22 figures from 12 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2008 [bc044349]
  1 figure (1 image) from Thisse et al., 2005 [eu81]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adipose tissue, blastoderm, blastodisc, blastomere (all 24) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la021455Tg, sa16405
Knockdown reagents: MO1-esr2a (1), MO2-esr2a (1), MO3-esr2a (1), MO4-esr2a (1)
PHENOTYPE
Data: 7 figures from 2 publications
Observed in: apoptotic process, basibranchial, brain, brain development (all 25) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular estrogen receptor signaling pathway (more)
Cellular Component nucleus (more)
Molecular Function estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000536 (1)
  • InterPro:IPR001628 (1)
  • InterPro:IPR001723 (1)
  • InterPro:IPR008946 (1)
  • InterPro:IPR013088 (1)
  • InterPro:IPR021064 (1)
  • InterPro:IPR024178 (1)
  • InterPro:IPR028355 (1)
  • PROSITE:PS00031 (1)
  • PROSITE:PS51030 (1)
  • Pfam:PF00104 (1)
  • Pfam:PF00105 (1)
  • Pfam:PF12497 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA esr2a-001 (1) 3249
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM esr2a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    esr2a Contained in: [BAC] DKEY-274C14 (1)
    esr2a Encodes: [EST] bc044349 (1) (order this), eu81 (1), fi14h07
    [cDNA] MGC:55251 (1) (order this), MGC:192492 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_180966 (1) 3111 bp
    Genomic GenBank:BX255911 (1) 206480 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7ZU32 (1) 553 aa
    Sequence Clusters UniGene:80416 (1)
    Sequence Information (all 30)
    OTHER esr2a GENE PAGES
  • Gene:317734 (1)
  • VEGA:OTTDARG00000004945 (1)
  • Ensembl(Zv9):ENSDARG00000016454 (1)
  • MAPPING INFORMATION
    Chr: 20 Details
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA NT
    Zebrafish esr2a 20  
    Human ESR2 14 (14q23.2)
  • OMIM:601663
  • Gene:2100
  • Mouse Esr2 12 ( 33.52 cM)
  • MGI:109392
  • Gene:13983
  • CITATIONS (59)