ZFIN ID: ZDB-GENE-030116-2
Gene Name: estrogen receptor 2a
Gene Symbol: esr2a
Previous Names: ER[b]2 (1), ER[b]a (1), ERbeta-B (1), NR3A2-B (1), zfER[b]2 (1)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 23 figures from 13 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2008 [bc044349]
  1 figure (1 image) from Thisse et al., 2005 [eu81]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adipose tissue, blastoderm, blastodisc, blastomere (all 24) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
la021455Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16405 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: CRISPR1-esr2a (1), MO1-esr2a (1), MO2-esr2a (1), MO3-esr2a (1), MO4-esr2a (1)
    PHENOTYPE
    Data: 7 figures from 2 publications
    Observed in: apoptotic process, basibranchial, brain, brain development (all 25) expand
    DISEASE ASSOCIATED WITH esr2a HUMAN ORTHOLOG No data available
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process response to estrogen (more)
    Cellular Component nucleus (more)
    Molecular Function RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000536 (1)
  • InterPro:IPR001628 (1)
  • InterPro:IPR001723 (1)
  • InterPro:IPR013088 (1)
  • InterPro:IPR021064 (1)
  • InterPro:IPR024178 (1)
  • InterPro:IPR028355 (1)
  • PROSITE:PS00031 (1)
  • PROSITE:PS51030 (1)
  • Pfam:PF00104 (1)
  • Pfam:PF00105 (1)
  • Pfam:PF12497 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA esr2a-001 (1) 3249
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM esr2a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    esr2aContained in: [BAC] DKEY-274C14 (1) (order this)
    esr2aEncodes: [EST] bc044349 (1) (order this), eu81 (1), fi14h07
    [cDNA] MGC:55251 (1) (order this), MGC:192492 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_180966 (1) 3111bp
    Genomic GenBank:BX255911 (1) 206480bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7ZU32 (1) 553aa
    Sequence Clusters UniGene:80416 (1)
    Sequence Information (all 38)
    OTHER esr2a GENE PAGES 
  • Gene:317734 (1)
  • VEGA:OTTDARG00000004945 (1)
  • Ensembl(GRCz10):ENSDARG00000016454 (1)
  • ORTHOLOGY for esr2a (Chr: 20) 
    Species Symbol Chromosome Accession # Evidence
    Human ESR2 14
  • Gene:2100
  • OMIM:601663
  • HGNC:3468
  • Amino acid sequence comparison (4)
    Nucleotide sequence comparison (1)
    Phylogenetic tree (1)
    Mouse Esr2 12
  • MGI:109392
  • Gene:13983
  • Amino acid sequence comparison (3)
    Nucleotide sequence comparison (1)
    Phylogenetic tree (1)
    Download Curated Orthology
    CITATIONS (85)