ZFIN ID: ZDB-GENE-030113-2
Gene Name: titin a
Gene Symbol: ttna
Previous Names: ttn, TTN2 (1), fi20g08, pickwick, pik, si:busm1-258d18.1, si:dz258d18.1, wu:fi04b11, wu:fi20g08
Location: Chr: 9   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 50 figures from 20 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [IMAGE:7153193]
  7 figures (18 images) from Thisse et al., 2004 [IMAGE:7157159]
  6 figures (15 images) from Thisse et al., 2004 [IMAGE:7159525]
  6 figures (11 images) from Thisse et al., 2004 [IMAGE:7148926]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  adaxial cell, adductor mandibulae, anterior lateral plate mesoderm, atrium (all 23) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 genotypes
Alleles: la026999Tg, la027000Tg, m171, m186, m242 (all 49) expand
Knockdown reagents: MO1-ttna (1), MO2-ttna (1)
PHENOTYPE
Data: 18 figures from 8 publications
Observed in: atrium, axon guidance, cardiac muscle cell A band, cardiac muscle cell myofibril (all 31) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Cardiomyopathy, dilated, 1G 604145
Cardiomyopathy, familial hypertrophic, 9 613765
Muscular dystrophy, limb-girdle, type 2J 608807
Myopathy, early-onset, with fatal cardiomyopathy 611705
Myopathy, proximal, with early respiratory muscle involvement 603689
Tibial muscular dystrophy, tardive 600334
GENE ONTOLOGY
Ontology GO Term
Biological Process cell morphogenesis (more)
Cellular Component nucleosome (more)
Molecular Function structural constituent of muscle (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR005819 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015129 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF09042 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002029 (1) 58230
    Select Tool
    ttna-001 (1) 67298
    Select Tool
    ttna-002 (1) 23044
    ttna-003 (1) 1201
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-ttn (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ttna
    Tg(ttna:actn2-EGFP), Tg(ttna:MA-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ttna Contained in: [BAC] DKEY-190I10 (1), DKEYP-67D2 (1)
    [PAC] BUSM1-258D18 (1) (order this)
    ttna Encodes: [EST] fi04b11, fi20g08 (1), fv57h12, IMAGE:7148926 (1) (order this), IMAGE:7153193 (1) (order this), IMAGE:7157159 (1) (order this), IMAGE:7159525 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:AY033829 3828 bp
    Genomic GenBank:DQ649453 (1) 441087 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5X6X5 (1) 32757 aa
    Sequence Information (all 25)
    OTHER ttna GENE PAGES
  • VEGA:OTTDARG00000001901 (1)
  • VEGA:OTTDARG00000021126 (1)
  • Ensembl(Zv9):ENSDARG00000028213 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ttna 9  
    Human TTN 2 (2q31)
  • OMIM:188840
  • Gene:7273
  • Orthology Details
    CITATIONS (58)