ZFIN ID: ZDB-GENE-030113-2
Gene Name: titin, tandem duplicate 2
Gene Symbol: ttn.2

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Previous Names: TTN2 (1), ttn, ttna, pickwick, pik, si:busm1-258d18.1, si:dz258d18.1, wu:fi04b11, wu:fi20g08

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 52 figures from 22 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [IMAGE:7153193]
  7 figures (18 images) from Thisse et al., 2004 [IMAGE:7157159]
  6 figures (15 images) from Thisse et al., 2004 [IMAGE:7159525]
  6 figures (11 images) from Thisse et al., 2004 [IMAGE:7148926]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  adaxial cell, adductor mandibulae, anterior lateral plate mesoderm, atrium (all 25) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026999Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027000Tg Transgenic Insertion Unknown Unknown DNA
    m171 Point Mutation Unknown Unknown ENU
    m186 Unknown Unknown Unknown ENU
    m242 Unknown Unknown Unknown ENU
    m740 Unknown Unknown Unknown ENU
    sa787 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1029 Point Mutation Unknown Nonsynonymous ENU
    sa1712 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1736 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2492 Point Mutation Unknown Premature Stop ENU
    sa2493 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2497 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2512 Point Mutation Unknown Premature Stop ENU
    sa8574 Point Mutation Unknown Premature Stop ENU
    sa8604 Point Mutation Unknown Premature Stop ENU
    sa8690 Point Mutation Unknown Premature Stop ENU
    sa9067 Point Mutation Unknown Premature Stop ENU
    sa9790 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa10365 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa11451 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11772 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12142 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12350 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12471 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12712 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12872 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12924 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13049 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13739 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13884 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14025 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14565 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14817 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15087 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15104 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15885 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16217 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16825 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16898 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17286 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18062 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18964 Point Mutation Unknown Premature Stop ENU
    sa21571 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21572 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21573 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21574 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21575 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21576 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21577 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21578 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21579 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21580 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21581 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21582 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21583 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21584 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21585 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25437 Point Mutation Unknown Premature Stop ENU
    sa30647 Point Mutation Unknown Splice Site ENU
    sa30924 Point Mutation Unknown Premature Stop ENU
    sa30925 Point Mutation Unknown Splice Site ENU
    sa31745 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31746 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31747 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34740 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34741 Point Mutation Unknown Premature Stop ENU
    sa34742 Point Mutation Unknown Premature Stop ENU
    sa34743 Point Mutation Unknown Premature Stop ENU
    sa34744 Point Mutation Unknown Premature Stop ENU
    sa34745 Point Mutation Unknown Premature Stop ENU
    sa34746 Point Mutation Unknown Premature Stop ENU
    sa34747 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34748 Point Mutation Unknown Premature Stop ENU
    sa38759 Point Mutation Unknown Premature Stop ENU
    sa38760 Point Mutation Unknown Premature Stop ENU
    sa38761 Point Mutation Unknown Premature Stop ENU
    sa41524 Point Mutation Unknown Premature Stop ENU
    sa41525 Point Mutation Unknown Premature Stop ENU
    sa41526 Point Mutation Unknown Premature Stop ENU
    sa41527 Point Mutation Unknown Premature Stop ENU
    sa41528 Point Mutation Unknown Premature Stop ENU
    sa41529 Point Mutation Unknown Premature Stop ENU
    sa41530 Point Mutation Unknown Splice Site ENU
    sa41531 Point Mutation Unknown Premature Stop ENU
    sa41532 Point Mutation Unknown Splice Site ENU
    sa41533 Point Mutation Unknown Premature Stop ENU
    sa41534 Point Mutation Unknown Splice Site ENU
    sa41535 Point Mutation Unknown Premature Stop ENU
    sa41536 Point Mutation Unknown Premature Stop ENU
    sa41538 Point Mutation Unknown Premature Stop ENU
    sa41539 Point Mutation Unknown Premature Stop ENU
    sa41540 Point Mutation Unknown Splice Site ENU
    sfc8 Insertion Unknown Frameshift CRISPR
    sfc9 Insertion Unknown Frameshift CRISPR
    sfc10 Small Deletion Unknown Unknown CRISPR
    sfc11 Small Deletion Unknown Frameshift CRISPR
    sfc12 Small Deletion Unknown Frameshift CRISPR
    sfc13 Insertion Unknown Frameshift CRISPR
    uw3 Unknown Unknown Unknown ENU
    Targeting reagents: CRISPR1-ttn.2 (1), CRISPR2-ttn.2 (1), CRISPR3-ttn.2 (1), CRISPR4-ttn.2 (1), CRISPR5-ttn.2 (1) (all 16) expand
    PHENOTYPE
    Data: 21 figures from 9 publications
    Observed in: atrium, axon guidance, cardiac muscle sarcomere, cardiac muscle cell A band (all 34) expand
    DISEASE ASSOCIATED WITH ttn.2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    autosomal recessive limb-girdle muscular dystrophy type 2J Muscular dystrophy, limb-girdle, type 2J 608807
    dilated cardiomyopathy 1G Cardiomyopathy, dilated, 1G 604145
    hypertrophic cardiomyopathy 9 Cardiomyopathy, familial hypertrophic, 9 613765
    Myopathy, proximal, with early respiratory muscle involvement 603689
    Myopathy, early-onset, with fatal cardiomyopathy 611705
    Tibial muscular dystrophy, tardive 600334
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle tissue development (more)
    Cellular Component nucleosome (more)
    Molecular Function structural constituent of muscle (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR005819 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013106 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015129 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF09042 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002029 (1) 58230
    Select Tool
    ttn.2-001 (1) 67298
    Select Tool
    ttn.2-002 (1) 23044
    ttn.2-003 (1) 1201
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab2-ttn (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ttn.2
    Tg(ttn.2:actn2-EGFP), Tg(ttn.2:MA-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ttn.2Contained in: [BAC] DKEY-190I10 (1) (order this), DKEYP-67D2 (1)
    [PAC] BUSM1-258D18 (1) (order this)
    ttn.2Encodes: [EST] fi04b11, fi20g08 (1), fv57h12, IMAGE:7148926 (1) (order this), IMAGE:7153193 (1) (order this), IMAGE:7157159 (1) (order this), IMAGE:7159525 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:AY033829 3828bp
    Genomic GenBank:DQ649453 (1) 441087bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5X6X5 (1) 32757aa
    Sequence Information (all 24)
    OTHER ttn.2 GENE PAGES
  • VEGA:OTTDARG00000001901 (1)
  • VEGA:OTTDARG00000021126 (1)
  • Ensembl(GRCz10):ENSDARG00000028213 (1)
  • ORTHOLOGY for ttn.2 (Chr: 9)
    Species Symbol Chromosome Accession # Evidence
    Human TTN 2
  • Gene:7273
  • OMIM:188840
  • HGNC:12403
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (3)
    Download Curated Orthology
    CITATIONS (68)