ZFIN Gene: ttna

ZFIN ID: ZDB-GENE-030113-2

ZFIN ID: ZDB-GENE-030113-2

Gene Name:	titin a
Gene Symbol:	ttna
Previous Names:	ttn, TTN2 (1), fi20g08, pickwick, pik, si:busm1-258d18.1, si:dz258d18.1, wu:fi04b11, wu:fi20g08
Nomenclature History

GENE EXPRESSION
All Expression Data:	46 figures from 17 publications
Directly Submitted Expression Data:	6 figures (16 images) from Thisse et al., 2004 [IMAGE:7153193]
	7 figures (18 images) from Thisse et al., 2004 [IMAGE:7157159]
	6 figures (15 images) from Thisse et al., 2004 [IMAGE:7159525]
	6 figures (11 images) from Thisse et al., 2004 [IMAGE:7148926]
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
	adaxial cell , anterior lateral plate mesoderm , atrium , cardiac muscle (all 17)
Curated Microarray Expression:	GEO (1)

MUTANTS AND TARGETED KNOCKDOWNS

PHENOTYPE

Data:	15 figures from 5 publications
Observed in:	atrium , axon guidance , cardiac muscle cell A band, cardiac muscle cell myofibril (all 27)

Phenotype of Human Orthologue	OMIM Phenotype ID
Cardiomyopathy, dilated, 1G	604145
Cardiomyopathy, familial hypertrophic, 9	613765
Muscular dystrophy, limb-girdle, type 2J	608807
Myopathy, early-onset, with fatal cardiomyopathy	611705
Myopathy, proximal, with early respiratory muscle involvement	603689
Tibial muscular dystrophy, tardive	600334

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cell morphogenesis (more)
Cellular Component	intracellular (more)
Molecular Function	structural constituent of muscle (more)

GO Terms (all 23)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000195 (1) InterPro:IPR000219 (1) InterPro:IPR000719 (1) InterPro:IPR001054 (1) InterPro:IPR003598 (1) InterPro:IPR003599 (1) InterPro:IPR003961 (1) InterPro:IPR005819 (1) InterPro:IPR007110 (1) InterPro:IPR008266 (1) InterPro:IPR008985 (1) InterPro:IPR009011 (1) InterPro:IPR011009 (1) InterPro:IPR011030 (1) InterPro:IPR012337 (1) InterPro:IPR013098 (1) InterPro:IPR013783 (1) InterPro:IPR015129 (1) InterPro:IPR016024 (1) InterPro:IPR022682 (1)	PROSITE:PS00109 (1) PROSITE:PS50011 (1) PROSITE:PS50835 (1) PROSITE:PS50853 (1)	Pfam:PF00041 (1) Pfam:PF00069 (1) Pfam:PF07679 (1) Pfam:PF09042 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	ottdart00000002029 (1)	58230	Select Tool MegaBLAST Ensembl
	ttna-001 (1)	67298	Select Tool MegaBLAST Ensembl
	ttna-002 (1)	23044	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega
	ttna-003 (1)	1201	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT Vega

GENE PRODUCT DESCRIPTION

ANTIBODIES

Ab2-ttn (1)

CONSTRUCTS WITH SEQUENCES FROM ttna

Tg(ttna:actn2-EGFP), Tg(ttna:MA-EGFP)

SEGMENT (CLONE AND PROBE) RELATIONSHIPS

ttna Contained in:	[BAC] DKEY-190I10 (1) (order this), DKEYP-67D2 (1) [PAC] BUSM1-258D18 (1) (order this)
ttna Encodes:	[EST] fi04b11, fi20g08 (1), fv57h12, IMAGE:7148926 (1) (order this), IMAGE:7153193 (1) (order this), IMAGE:7157159 (1) (order this), IMAGE:7159525 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:XM_001923765 (1)	99304 bp	Select Tool MegaBLAST Ensembl
Genomic	GenBank:DQ649453 (1)	441087 bp	Blast at MegaBLAST
Polypeptide	UniProtKB:A5X6X5 (1)	32757 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast Vega Protein Blast
Sequence Clusters	UniGene:80676 (1)

OTHER ttna GENE PAGES

Gene:317731 (1)

VEGA:OTTDARG00000001901 (1)

VEGA:OTTDARG00000021126 (1)

Ensembl(Zv9):ENSDARG00000028213 (1)

MAPPING INFORMATION
Chr: 9 Details	View Map: Merged Individual Panels

ORTHOLOGY

CITATIONS (55)