ZFIN ID: ZDB-GENE-030113-2
Gene Name: titin a
Gene Symbol: ttna
Previous Names: TTN2 (1), ttn, fi20g08, pickwick, pik, si:busm1-258d18.1, si:dz258d18.1, wu:fi04b11, wu:fi20g08
Location: Chr: 9   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 50 figures from 20 publications
Directly Submitted Expression Data: 6 figures (16 images) from Thisse et al., 2004 [IMAGE:7153193]
  7 figures (18 images) from Thisse et al., 2004 [IMAGE:7157159]
  6 figures (15 images) from Thisse et al., 2004 [IMAGE:7159525]
  6 figures (11 images) from Thisse et al., 2004 [IMAGE:7148926]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  adaxial cell, adductor mandibulae, anterior lateral plate mesoderm, atrium (all 24) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 17 Genotypes
Knockdown reagents: MO1-ttna (1), MO2-ttna (1)

Allele Type Mutagen Suppliers
la026999Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027000Tg Transgenic Insertion DNA
    m171 Point Mutation ENU
    m186 Unknown ENU
    m242 Unknown ENU
    m740 Unknown ENU
    sa787 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1712 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1736 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2492 Point Mutation ENU
    sa2493 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2497 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9790 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa10365 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa11451 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa11772 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12142 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12350 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12471 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12712 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12872 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa12924 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13049 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13739 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13884 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14025 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14565 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa14817 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15087 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15104 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15885 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16217 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16825 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa16898 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa17286 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18062 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21571 Point Mutation ENU
    sa21573 Point Mutation ENU
    sa21574 Point Mutation ENU
    sa21575 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa21576 Point Mutation ENU
    sa21578 Point Mutation ENU
    sa21580 Point Mutation ENU
    sa21581 Point Mutation ENU
    sa21582 Point Mutation ENU
    sa21583 Point Mutation ENU
    sa21584 Point Mutation ENU
    sa21585 Point Mutation ENU
    uw3 Unknown ENU
    PHENOTYPE
    Data: 18 figures from 8 publications
    Observed in: atrium, axon guidance, cardiac muscle cell A band, cardiac muscle cell myofibril (all 31) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Cardiomyopathy, dilated, 1G 604145
    Cardiomyopathy, familial hypertrophic, 9 613765
    Muscular dystrophy, limb-girdle, type 2J 608807
    Myopathy, early-onset, with fatal cardiomyopathy 611705
    Myopathy, proximal, with early respiratory muscle involvement 603689
    Tibial muscular dystrophy, tardive 600334
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell morphogenesis (more)
    Cellular Component nucleosome (more)
    Molecular Function structural constituent of muscle (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR005819 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR015129 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF09042 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002029 (1) 58230
    Select Tool
    ttna-001 (1) 67298
    Select Tool
    ttna-002 (1) 23044
    ttna-003 (1) 1201
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-ttn (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ttna
    Tg(ttna:actn2-EGFP), Tg(ttna:MA-EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ttna Contained in: [BAC] DKEY-190I10 (1) (order this), DKEYP-67D2 (1)
    [PAC] BUSM1-258D18 (1) (order this)
    ttna Encodes: [EST] fi04b11, fi20g08 (1), fv57h12, IMAGE:7148926 (1) (order this), IMAGE:7153193 (1) (order this), IMAGE:7157159 (1) (order this), IMAGE:7159525 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:AY033829 3828 bp
    Genomic GenBank:DQ649453 (1) 441087 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A5X6X5 (1) 32757 aa
    Sequence Information (all 25)
    OTHER ttna GENE PAGES
  • VEGA:OTTDARG00000001901 (1)
  • VEGA:OTTDARG00000021126 (1)
  • Ensembl(Zv9):ENSDARG00000028213 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ttna 9  
    Human TTN 2 (2q31)
  • OMIM:188840
  • Gene:7273
  • Orthology Details
    CITATIONS (61)