Gene

ruvbl1

ID

ZDB-GENE-030109-2

Name

RuvB-like AAA ATPase 1

Symbol

ruvbl1 Nomenclature History

Previous Names

pontin (1)
TIP49 (1)
wu:fd18e04
zpontin

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have DNA helicase activity. Involved in several processes, including axonemal dynein complex assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Localizes to cytosol. Is expressed in neural tube; neuromast; peripheral olfactory organ; and pronephric tubule. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ruvbl1 Human Ortholog

No data available

Associated With ruvbl1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR010339	TIP49, P-loop domain
Domain	IPR041048	RuvB-like, AAA-lid domain
Family	IPR027238	RuvB-like
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR042487	RuvBL1/2, DNA/RNA binding domain