Gene

ruvbl1

ID
ZDB-GENE-030109-2
Name
RuvB-like AAA ATPase 1
Symbol
ruvbl1 Nomenclature History
Previous Names
  • pontin (1)
  • TIP49 (1)
  • wu:fd18e04
  • zpontin
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable DNA helicase activity. Acts upstream of or within several processes, including axonemal dynein complex assembly; epithelial cilium movement involved in extracellular fluid movement; and regulation of heart growth. Located in cytosol. Is expressed in neural tube; neuromast; peripheral olfactory organ; and pronephric tubule. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ruvbl1 Human Ortholog
No data available
Associated With ruvbl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR010339 TIP49, P-loop domain
Domain IPR041048 RuvB-like, AAA-lid domain
Family IPR027238 RuvB-like
Family IPR037938 RuvB-like helicase 1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR042487 RuvBL1/2, DNA/RNA binding domain
Domain Details Per Protein
Protein Length AAA+ ATPase domain P-loop containing nucleoside triphosphate hydrolase RuvBL1/2, DNA/RNA binding domain RuvB-like RuvB-like, AAA-lid domain RuvB-like helicase 1 TIP49, P-loop domain
UniProtKB:Q6TGU6 456
UniProtKB:Q6IQT8 456
UniProtKB:Q8AWW7 456
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ruvbl1 polyclonal Rabbit
  • IHC
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations