Gene
neo1a
- ID
- ZDB-GENE-021031-1
- Name
- neogenin 1a
- Symbol
- neo1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Acts upstream of or within cell morphogenesis; neural tube formation; and somitogenesis. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in several structures, including nervous system; neural rod; pectoral fin; pleuroperitoneal region; and splanchnocranium. Orthologous to human NEO1 (neogenin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109795 (1 image)
- cb333 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011151Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016169Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la016170Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026154Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mn0231Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| p213 | unknown | Unknown | Unknown | not specified | |
| sa6086 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11491 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17579 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21085 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-neo1a | Brown et al., 2019 | |
| CRISPR2-neo1a | Brown et al., 2019 | |
| CRISPR3-neo1a | (2) | |
| CRISPR4-neo1a | (2) | |
| MO1-neo1a | N/A | Mawdsley et al., 2004 |
| MO2-neo1a | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Neogenin, C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IP15
|
1428 | |||||||||
|
UniProtKB:A0A8M2BE14
|
1431 | |||||||||
|
UniProtKB:A0A8M3AUJ2
|
1439 | |||||||||
|
UniProtKB:A0A0R4IIB3
|
1409 | |||||||||
|
UniProtKB:A0A8M3BBA1
|
1449 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-126F20 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-47G1 | ZFIN Curated Data | |
| Encodes | EST | cb333 | Thisse et al., 2001 | |
| Encodes | EST | fq38a06 | Rauch et al., 2003 | |
| Encodes | cDNA | cssl:d230 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:109795 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173218 (1) | 6254 nt | ||
| Genomic | GenBank:BX927325 (2) | 208845 nt | ||
| Polypeptide | UniProtKB:A0A8M3AUL1 (1) | 1450 aa |
- Dang, P., Barnes, D.T., Cheng, R.P., Xu, A., Ji Moon, Y., Sripad Kodukula, S., Raper, J.A. (2022) Netrins and netrin receptors are essential for normal targeting of sensory axons in the zebrafish olfactory bulb. Neuroscience. 508:19-29
- Höijer, I., Emmanouilidou, A., Östlund, R., van Schendel, R., Bozorgpana, S., Tijsterman, M., Feuk, L., Gyllensten, U., den Hoed, M., Ameur, A. (2022) CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations. Nature communications. 13:627
- von der Heyde, B., Emmanouilidou, A., Mazzaferro, E., Vicenzi, S., Höijer, I., Klingström, T., Jumaa, S., Dethlefsen, O., Snieder, H., de Geus, E., Ameur, A., Ingelsson, E., Allalou, A., Brooke, H.L., den Hoed, M. (2020) Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. Scientific Reports. 10:11831
- Brown, S., Jayachandran, P., Negesse, M., Olmo, V., Vital, E., Brewster, R. (2019) Rgma-induced Neo1 proteolysis promotes neural tube morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(38):7465-7484
- Wang, Y., Han, Y., Xu, P., Ding, S., Li, G., Jin, H., Meng, Y., Meng, A., Jia, S. (2018) prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 45(8):443-453
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Madgwick, A., Fort, P., Hanson, P.S., Thibault, P., Gaudreau, M.C., Lutfalla, G., Möröy, T., Abou Elela, S., Chaudhry, B., Elliott, D.J., Morris, C.M., Venables, J.P. (2015) Neural Differentiation Modulates the Vertebrate Brain Specific Splicing Program. PLoS One. 10:e0125998
- Du, T.T., Xu, P.F., Dong, Z.W., Fan, H.B., Jin, Y., Dong, M., Chen, Y., Pan, W.J., Ren, R.B., Liu, T.X., Deng, M., Huang, Q.H. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Developmental Biology. 392(2):233-44
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gao, J., Zhang, C., Yang, B., Sun, L., Zhang, C., Westerfield, M., and Peng, G. (2012) Dcc Regulates Asymmetric Outgrowth of Forebrain Neurons in Zebrafish. PLoS One. 7(5):e36516
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