Gene
ptgs2a
- ID
- ZDB-GENE-020530-2
- Name
- prostaglandin-endoperoxide synthase 2a
- Symbol
- ptgs2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables peroxidase activity. Acts upstream of or within several processes, including embryonic liver development; exocrine pancreas development; and pronephros development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and neuron projection. Is expressed in several structures, including cardiovascular system; digestive system; gonad; head; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; arthritis (multiple); cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 32 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa90 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10104 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11800 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16633 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25105 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa44528 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zf3102 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ptgs2a | Thomas et al., 2014 | |
| CRISPR2-ptgs2a | (2) | |
| CRISPR3-ptgs2a | Lu et al., 2023 | |
| CRISPR4-ptgs2a | Lu et al., 2023 | |
| CRISPR5-ptgs2a | Lu et al., 2023 | |
| MO1-ptgs2a | N/A | (7) |
| MO2-ptgs2a | N/A | (4) |
| MO3-ptgs2a | N/A | Teraoka et al., 2009 |
| MO4-ptgs2a | N/A | (2) |
| MO5-ptgs2a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000742 | EGF-like domain |
| Family | IPR019791 | Haem peroxidase, animal-type |
| Family | IPR050783 | Oxylipin biosynthesis and metabolism |
| Homologous_superfamily | IPR010255 | Haem peroxidase superfamily |
| Homologous_superfamily | IPR037120 | Haem peroxidase domain superfamily, animal type |
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Domain Details Per Protein
| Protein | Additional Resources | Length | EGF-like domain | Haem peroxidase, animal-type | Haem peroxidase domain superfamily, animal type | Haem peroxidase superfamily | Oxylipin biosynthesis and metabolism |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q8JH43 | InterPro | 601 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptgs2a-201
(1)
|
Ensembl | 2,135 nt | ||
| ncRNA |
ptgs2a-002
(1)
|
Ensembl | 673 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-147D18 | ZFIN Curated Data | |
| Contains | SNP | rs3727618 | ZFIN Curated Data | |
| Contains | SNP | rs3727619 | ZFIN Curated Data | |
| Encodes | EST | fj02a10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66037 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77710 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_153657 (1) | 2150 nt | ||
| Genomic | GenBank:CU570979 (1) | 93361 nt | ||
| Polypeptide | UniProtKB:Q8JH43 (1) | 601 aa |
- Liu, Y., Lin, S., Wang, C., Li, T., Zheng, G., Sun, W., An, L., Bai, Y., Wu, F. (2024) Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio). Environmental science & technology. 58(35):15450-15462
- Yi, R., Yang, B., Zhu, H., Sun, Y., Wu, H., Wang, Z., Lu, Y., He, Y.W., Tian, J. (2024) Quorum-Sensing Signal DSF Inhibits the Proliferation of Intestinal Pathogenic Bacteria and Alleviates Inflammatory Response to Suppress DSS-Induced Colitis in Zebrafish. Nutrients. 16(11):
- Ernst, A., Piragyte, I., Mp, A.M., Le, N.D., Grandgirard, D., Leib, S.L., Oates, A., Mercader, N. (2023) Identification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform. Scientific Reports. 13:1703717037
- Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
- Liu, Q., Song, T., Chen, B., Zhang, J., Li, W. (2023) Ferroptosis of brain microvascular endothelial cells contributes to hypoxia-induced blood-brain barrier injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37:e22874e22874
- Liu, X., Yu, T., Tan, X., Jin, D., Yang, W., Zhang, J., Dai, L., He, Z., Li, D., Zhang, Y., Liao, S., Zhao, J., Zhong, T.P., Liu, C. (2023) Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2. eLIFE. 12:
- Lu, F., Leach, L.L., Gross, J.M. (2023) A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium. Scientific Reports. 13:31423142
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Ma, Y., Hui, K.L., Gelashvili, Z., Niethammer, P. (2023) Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish. Cell Reports. 42:111974111974
- Novichkova, E., Nayak, S., Boussiba, S., Gopas, J., Zilberg, D., Khozin-Goldberg, I. (2023) Dietary Application of the Microalga Lobosphaera incisa P127 Reduces Severity of Intestinal Inflammation, Modulates Gut-Associated Gene Expression and Microbiome in the Zebrafish Model of IBD. Molecular Nutrition & Food Research. 67(6):e2200253
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