Gene
gpia
- ID
- ZDB-GENE-020513-2
- Name
- glucose-6-phosphate isomerase a
- Symbol
- gpia Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable glucose-6-phosphate isomerase activity and monosaccharide binding activity. Predicted to be involved in gluconeogenesis; glucose 6-phosphate metabolic process; and glycolytic process. Predicted to act upstream of or within carbohydrate derivative metabolic process. Predicted to be located in extracellular space. Predicted to be active in cytosol. Is expressed in several structures, including digestive system; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 4; intellectual disability; and neuromuscular disease. Orthologous to human GPI (glucose-6-phosphate isomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55667 (24 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital nonspherocytic hemolytic anemia 4 | Alliance | Anemia, congenital, nonspherocytic hemolytic, 4, glucose phosphate isomerase deficient | 613470 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018189 | Phosphoglucose isomerase, conserved site |
| Domain | IPR035476 | Phosphoglucose isomerase, SIS domain 1 |
| Domain | IPR035482 | Phosphoglucose isomerase, SIS domain 2 |
| Family | IPR001672 | Phosphoglucose isomerase (PGI) |
| Homologous_superfamily | IPR023096 | Phosphoglucose isomerase, C-terminal |
| Homologous_superfamily | IPR046348 | SIS domain superfamily |
Domain Details Per Protein
| Protein | Length | Phosphoglucose isomerase, conserved site | Phosphoglucose isomerase, C-terminal | Phosphoglucose isomerase (PGI) | Phosphoglucose isomerase, SIS domain 1 | Phosphoglucose isomerase, SIS domain 2 | SIS domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8QFU2
|
553 |
Interactions and Pathways
No data available
Plasmids
No data available