Gene
klf2a
- ID
- ZDB-GENE-011109-1
- Name
- Kruppel like factor 2a
- Symbol
- klf2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within circulatory system development; nitric oxide biosynthetic process; and regulation of cell fate specification. Is expressed in several structures, including EVL; cardiovascular system; cloaca; fin; and pectoral fin bud. Orthologous to human KLF2 (KLF transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 55 figures from 41 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns11 | Allele with one deletion | Unknown | Unknown | TALEN | |
| fdu031 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| ig4 | Allele with one delins | Exon 1 | Premature Stop | TALEN | |
| sa24120 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30728 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sh317 | Allele with one deletion | Exon 2 | Premature Stop | TALEN | |
| y616 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-klf2a | (2) | |
| CRISPR2-klf2a | Li et al., 2020 | |
| CRISPR3-klf2a | Stratman et al., 2020 | |
| MO1-klf2a | N/A | (9) |
| MO2-klf2a | N/A | (5) |
| MO3-klf2a | N/A | (3) |
| MO4-klf2a | N/A | (3) |
| MO5-klf2a | N/A | (2) |
| MO6-klf2a | N/A | Wang et al., 2013 |
| TALEN1-klf2a | (7) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
| UniProtKB:Q1LXI7 | InterPro | 380 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:LOXP-TagBFP-STOP-LOXP-3xHA-klf2a) |
| 1 | (3) | ||
| TgBAC(klf2a:Citrine) |
|
| 1 | (5) | |
| Tg(hsp70l:klf2a,EGFP) |
|
| 1 | (3) | |
| Tg(hsp70l:klf2a-IRES-EGFP) |
| 1 | Donat et al., 2018 | ||
| Tg(klf2a:GFP) |
|
| 1 | Chhabria et al., 2019 | |
| Tg(klf2a:H2b-EGFP) |
|
| 1 | (6) | |
| Tg(myl7:klf2a-2A-tdTomato) |
| 1 | Rasouli et al., 2018 | ||
| Tg(UAS:klf2a) |
|
| 3 | (5) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-171D11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-192M14 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-70F9 | ZFIN Curated Data | |
| Encodes | EST | fb08e06 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77570 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131856 (1) | 2180 nt | ||
| Genomic | GenBank:BX323550 (1) | 200031 nt | ||
| Polypeptide | UniProtKB:Q1LXI7 (1) | 380 aa |
- Li, X., Yang, S., Zhang, X., Zhang, Y., Zhang, Y., Li, H. (2024) Bioinformatic Analysis of Roquin Family Reveals Their Potential Role in Immune System. International Journal of Molecular Sciences. 25(11):
- Pham, V.C., Rödel, C.J., Valentino, M., Malinverno, M., Paolini, A., Münch, J., Pasquier, C., Onyeogaziri, F.C., Lazovic, B., Girard, R., Koskimäki, J., Hußmann, M., Keith, B., Jachimowicz, D., Kohl, F., Hagelkruys, A., Penninger, J.M., Schulte-Merker, S., Awad, I.A., Hicks, R., Magnusson, P.U., Faurobert, E., Pagani, M., Abdelilah-Seyfried, S. (2024) Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Molecular Medicine. 16(11):2827-2855
- Weeks, O., Gao, X., Basu, S., Galdieri, J., Chen, K., Burns, C.G., Burns, C.E. (2024) Embryonic alcohol exposure in zebrafish predisposes adults to cardiomyopathy and diastolic dysfunction. Cardiovascular research. 120(13):1607-1621
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Grdseloff, N., Boulday, G., Rödel, C.J., Otten, C., Vannier, D.R., Cardoso, C., Faurobert, E., Dogra, D., Tournier-Lasserve, E., Abdelilah-Seyfried, S. (2023) Impaired retinoic acid signaling in cerebral cavernous malformations. Scientific Reports. 13:55725572
- Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):
- Juan, T., Ribeiro da Silva, A., Cardoso, B., Lim, S., Charteau, V., Stainier, D.Y.R. (2023) Multiple pkd and piezo gene family members are required for atrioventricular valve formation. Nature communications. 14:214214
- Li, H., Luo, Q., Cai, S., Tie, R., Meng, Y., Shan, W., Xu, Y., Zeng, X., Qian, P., Huang, H. (2023) Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Research & Therapy. 14:117117
- Paolini, A., Sharipova, D., Lange, T., Abdelilah-Seyfried, S. (2023) Wnt9 directs zebrafish heart tube assembly via a combination of canonical and non-canonical pathway signaling. Development (Cambridge, England). 150(18):
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