Gene
enah
- ID
- ZDB-GENE-010323-11
- Name
- ENAH actin regulator
- Symbol
- enah Nomenclature History
- Previous Names
-
- id:ibd2798
- si:ch211-215p14.1
- zgc:103638
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable profilin binding activity. Predicted to be involved in actin polymerization or depolymerization; actin polymerization-dependent cell motility; and axon guidance. Predicted to act upstream of or within intracellular transport. Predicted to be located in cytoplasm; cytoskeleton; and lamellipodium. Predicted to be active in focal adhesion and plasma membrane. Is expressed in paraxial mesoderm and somite. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ENAH (ENAH actin regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013876Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa37113 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37114 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PH-like domain superfamily | Ran binding domain | VASP tetramerisation | VASP tetramerisation domain superfamily | WH1/EVH1 domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PHA3 | InterPro | 616 | |||||
| UniProtKB:A0A8M3B453 | InterPro | 561 | |||||
| UniProtKB:A0A8M3AT84 | InterPro | 701 | |||||
| UniProtKB:A0A8M3B449 | InterPro | 824 | |||||
| UniProtKB:A0A8M3ALJ4 | InterPro | 799 | |||||
| UniProtKB:A0A8M3AKV4 | InterPro | 581 | |||||
| UniProtKB:A0A8M9PSN4 | InterPro | 596 | |||||
| UniProtKB:Q5TZC8 | InterPro | 804 | |||||
| UniProtKB:A0A8M3AW91 | InterPro | 796 | |||||
| UniProtKB:A0A0R4IB53 | InterPro | 533 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215P14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-1J5 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-112F21 | ZFIN Curated Data | |
| Encodes | EST | ibd2798 | ||
| Encodes | cDNA | MGC:103638 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045028 (1) | 4996 nt | ||
| Genomic | GenBank:BX000468 (2) | 208583 nt | ||
| Polypeptide | UniProtKB:A0A8M3B449 (1) | 824 aa |
- Yin, H.M., Yan, L.F., Liu, Q., Peng, Z., Zhang, C.Y., Xia, Y., Su, D., Gu, A.H., Zhou, Y. (2020) Activating transcription factor 3 coordinates differentiation of cardiac and hematopoietic progenitors by regulating glucose metabolism. Science advances. 6:eaay9466
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Otten, C., van der Ven, P.F., Lewrenz, I., Paul, S., Steinhagen, A., Busch-Nentwich, E., Eichhorst, J., Wiesner, B., Stemple, D., Strähle, U., Fürst, D.O., and Abdelilah-Seyfried, S. (2012) Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7(2):e31041
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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