Gene

rgl2

ID

ZDB-GENE-010131-1

Name

ral guanine nucleotide dissociation stimulator-like 2

Symbol

rgl2 Nomenclature History

Previous Names

im:7136742
rab2l (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7136742 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rgl2 Human Ortholog

No data available

Associated With rgl2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019804	Ras guanine-nucleotide exchange factor, conserved site
Domain	IPR000159	Ras-associating domain
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily