Gene
adar
- ID
- ZDB-GENE-000616-5
- Name
- adenosine deaminase RNA specific
- Symbol
- adar Nomenclature History
- Previous Names
-
- drada
- red1
- wu:fc22a02 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Acts upstream of or within anterior/posterior axis specification, embryo. Predicted to be active in cytoplasm and nucleolus. Is expressed in brain and nervous system. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu29 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Niescierowicz et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Aicardi-Goutieres syndrome | Alliance | Aicardi-Goutieres syndrome 6 | 615010 |
| dyschromatosis symmetrica hereditaria | Alliance | Dyschromatosis symmetrica hereditaria | 127400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002466 | Adenosine deaminase/editase |
| Domain | IPR014720 | Double-stranded RNA-binding domain |
| Domain | IPR042371 | Z-binding domain |
| Domain | IPR044456 | ADAR1, first double-stranded RNA binding domain |
| Domain | IPR044457 | ADAR1, third double-stranded RNA binding domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | ADAR1, first double-stranded RNA binding domain | ADAR1, third double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Z-binding domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P8J0
|
1381 |
Interactions and Pathways
No data available
Plasmids
No data available