ZFIN ID: ZDB-GENE-000403-1
Gene Name: axin 1
Gene Symbol: axin1
Previous Names: masterblind, mbl, wu:fi22e03, wu:fj14c08, wu:fk11b03 (1), zgc:109872
Location: Chr: 3   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  forebrain, habenula, midbrain, unspecified
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 13 genotypes
Alleles: la028927Tg, sa20109, tm13, tm213
Knockdown reagents: MO1-axin1 (1), MO2-axin1 (1)
PHENOTYPE
Data: 25 figures from 13 publications
Observed in: adenohypophysis, anterior commissure, blood circulation, brain (all 45) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Caudal duplication anomaly 607864
Hepatocellular carcinoma, somatic 114550
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of JUN kinase activity (more)
Cellular Component beta-catenin destruction complex (more)
Molecular Function protein homodimerization activity (more)
GO Terms (all 43)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000342 (1)
  • InterPro:IPR001158 (1)
  • InterPro:IPR014936 (1)
  • InterPro:IPR016137 (1)
  • InterPro:IPR024066 (1)
  • InterPro:IPR029071 (1)
  • PROSITE:PS50132 (1)
  • PROSITE:PS50841 (1)
  • Pfam:PF00615 (1)
  • Pfam:PF00778 (1)
  • Pfam:PF08833 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA axin1-001 (1) 4734
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM axin1
    Tg(hsp70l:GFP-axin1)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    axin1 Contained in: [BAC] CH73-54I21 (1) (order this), CH211-25B15 (1) (order this)
    axin1 Contains: [SNP] rs3727728 (1), rs3727729 (1)
    axin1 Encodes: [EST] fi22e03 (1), fj14c08 (1), fk11b03 (1)
    [cDNA] MGC:109872 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131503 (1) 4742 bp
    Genomic GenBank:CU138533 (1) 115648 bp
    Select Tool
    Polypeptide UniProtKB:F1QKZ5 (1) 835 aa
    Sequence Clusters UniGene:80549 (1)
    Sequence Information (all 21)
    OTHER axin1 GENE PAGES
  • Gene:57931 (1)
  • VEGA:OTTDARG00000035203 (1)
  • Ensembl(Zv9):ENSDARG00000026534 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish axin1 3  
    Human AXIN1 16 (16p13.3)
  • OMIM:603816
  • Gene:8312
  • Mouse Axin1 17 ( 13.07 cM)
  • MGI:1096327
  • Gene:12005
  • Orthology Details
    CITATIONS (78)