ZFIN ID: ZDB-GENE-000403-1
Gene Name: axin 1
Gene Symbol: axin1
Previous Names: masterblind, mbl, wu:fi22e03, wu:fj14c08, wu:fk11b03 (1), zgc:109872
Location: Chr: 3   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  forebrain, habenula, midbrain, unspecified (all 5) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 14 Genotypes
Knockdown reagents: MO1-axin1 (1), MO2-axin1 (1)

Allele Type Mutagen Suppliers
la028927Tg Transgenic Insertion DNA
sa20109 Point Mutation ENU
tm13 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Nüsslein-Volhard Lab
  • tm213 Point Mutation
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 26 figures from 14 publications
    Observed in: adenohypophysis, anterior commissure, blood circulation, brain (all 46) expand
    DISEASE ASSOCIATED WITH axin1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hepatocellular carcinoma Hepatocellular carcinoma, somatic 114550
    ?Caudal duplication anomaly 607864
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of JUN kinase activity (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function protein homodimerization activity (more)
    GO Terms (all 46)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001158 (1)
  • InterPro:IPR014936 (1)
  • InterPro:IPR016137 (1)
  • InterPro:IPR024066 (1)
  • InterPro:IPR029071 (1)
  • InterPro:IPR029797 (1)
  • PROSITE:PS50132 (1)
  • PROSITE:PS50841 (1)
  • Pfam:PF00615 (1)
  • Pfam:PF00778 (1)
  • Pfam:PF08833 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA axin1-001 (1) 4734
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM axin1
    Tg(hsp70l:GFP-axin1)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    axin1 Contained in: [BAC] CH73-54I21 (1) (order this), CH211-25B15 (1) (order this)
    axin1 Contains: [SNP] rs3727728 (1), rs3727729 (1)
    axin1 Encodes: [EST] fi22e03 (1), fj14c08 (1), fk11b03 (1)
    [cDNA] MGC:109872 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131503 (1) 4742 bp
    Genomic GenBank:CU138533 (1) 115648 bp
    Select Tool
    Polypeptide UniProtKB:F1QKZ5 (1) 835 aa
    Sequence Clusters UniGene:80549 (1)
    Sequence Information (all 21)
    OTHER axin1 GENE PAGES
  • Gene:57931 (1)
  • VEGA:OTTDARG00000035203 (1)
  • Ensembl(Zv9):ENSDARG00000026534 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish axin1 3  
    Human AXIN1 16 (16p13.3)
  • OMIM:603816
  • Gene:8312
  • Mouse Axin1 17 ( 13.07 cM)
  • MGI:1096327
  • Gene:12005
  • Orthology Details
    CITATIONS (82)