Gene
notch2
- ID
- ZDB-GENE-000329-4
- Name
- notch receptor 2
- Symbol
- notch2 Nomenclature History
- Previous Names
-
- notch6
- sb:cb884
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including animal organ development; face morphogenesis; and lymphangiogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Orthologous to human NOTCH2 (notch receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 42 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb884 (11 images)
- eu314 (4 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alagille syndrome | Alliance | Alagille syndrome 2 | 610205 |
| Hajdu-Cheney syndrome | Alliance | Hajdu-Cheney syndrome | 102500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000800 | Notch domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR010660 | Notch, NOD domain |
| Domain | IPR011656 | Notch, NODP domain |
| Domain | IPR024600 | Notch, C-terminal |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR008297 | Notch |
| Family | IPR022336 | Neurogenic locus notch homolog protein 2 |
| Family | IPR050906 | Notch signaling pathway |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR035993 | Notch-like domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR002110 | Ankyrin repeat |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Neurogenic locus notch homolog protein 2 | Notch | NOTCH1 EGF-like calcium-binding domain | Notch, C-terminal | Notch domain | Notch-like domain superfamily | Notch, NOD domain | Notch, NODP domain | Notch signaling pathway |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1RCH4
|
2475 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
notch2-201
(1)
|
Ensembl | 10,095 nt |
Interactions and Pathways
No data available
Plasmids
No data available