Gene
zic1
- ID
- ZDB-GENE-000208-4
- Name
- zic family member 1 (odd-paired homolog, Drosophila)
- Symbol
- zic1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in brain development and embryonic retina morphogenesis in camera-type eye. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Is expressed in several structures, including central nervous system; neural keel; neural plate; neural rod; and presumptive neural plate. Orthologous to human ZIC1 (Zic family member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 74 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76803 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis 6 | Alliance | ?Craniosynostosis 6 | 616602 |
| Structural brain anomalies with impaired intellectual development and craniosynostosis | 618736 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GLI C2H2-type zinc-finger | ZIC protein, zinc finger domain | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|
|
UniProtKB:O93311
|
442 |
Interactions and Pathways
No data available
Plasmids
No data available