Gene

foxe1

ID

ZDB-GENE-061116-1

Name

forkhead box E1

Symbol

foxe1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic viscerocranium morphogenesis and growth plate cartilage chondrocyte proliferation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and thyroid gland papillary carcinoma. Is expressed in several structures, including central nervous system; endocrine system; head; notochord; and pharynx. Orthologous to human FOXE1 (forkhead box E1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxe1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bamforth-Lazarus syndrome	Alliance	Bamforth-Lazarus syndrome	241850
		{Thyroid cancer, nonmedullary, 4}	616534

Associated With foxe1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Fork head domain	Fork head domain conserved site1	Fork head domain conserved site 2	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M2B6T0 InterPro	354

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	foxe1-202 (1) Ensembl	Havana	1383 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-foxe1	polyclonal	foxe1	IgG	Rabbit	IHC	Boster Biological	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations