Gene
foxe1
- ID
- ZDB-GENE-061116-1
- Name
- forkhead box E1
- Symbol
- foxe1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic viscerocranium morphogenesis and growth plate cartilage chondrocyte proliferation. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; endocrine system; head; notochord; and pharynx. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and thyroid gland papillary carcinoma. Orthologous to human FOXE1 (forkhead box E1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Nakada et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bamforth-Lazarus syndrome | Alliance | Bamforth-Lazarus syndrome | 241850 |
| {Thyroid cancer, nonmedullary, 4} | 616534 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:R4GEW1
|
375 | |||||
|
UniProtKB:E7EZ33
|
348 |
Interactions and Pathways
No data available
Plasmids
No data available