ZFIN Gene: foxe1

ZFIN ID: ZDB-GENE-061116-1

ZFIN ID: ZDB-GENE-061116-1

Gene Name:

forkhead box E1

Gene Symbol:

foxe1 Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 1 Mapping Details/Browsers

Description:

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic viscerocranium morphogenesis and growth plate cartilage chondrocyte proliferation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; endocrine system; head; notochord; and pharynx. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and thyroid gland papillary carcinoma. Orthologous to human FOXE1 (forkhead box E1).

Genome Resources:

Alliance (1), Gene:567676 (1), Ensembl(GRCz11):ENSDARG00000079266 (1)

GENE EXPRESSION
All Expression Data:	2 figures from 2 publications
Wild-type Stages, Structures:	Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
	brain central nervous system ceratobranchial cartilage eye gill heart notochord oral epithelium oral region epithelium pharyngeal arch epithelium pharyngeal arch pharyngeal epithelium pharynx splanchnocranium thyroid follicle thyroid primordium whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa32687	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa39620	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-foxe1	N/A	1
MO2-foxe1	N/A	1

PHENOTYPE

Data:	3 figures from Nakada et al., 2009
Observed in:	apoptotic process ceratobranchial cartilage ceratohyal cartilage embryonic viscerocranium morphogenesis growth plate cartilage chondrocyte proliferation head hyosymplectic cartilage Meckel's cartilage mouth post-vent region ventral mandibular arch

DISEASE ASSOCIATED WITH foxe1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bamforth-Lazarus syndrome	Alliance	Bamforth-Lazarus syndrome	241850
		{Thyroid cancer, nonmedullary, 4}	616534

DISEASE ASSOCIATED WITH foxe1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	embryonic viscerocranium morphogenesis (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	foxe1-202 (1)	1383	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM foxe1 No data available

MARKER RELATIONSHIPS

foxe1 Contained in:

[BAC] DKEY-25O16 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005159910 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:BX005000 (1)	234373 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:R4GEW1 (1)	375 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 7)

ORTHOLOGY for foxe1 ( Chr: 1 )

CITATIONS (19)

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