ZFIN ID: ZDB-GENE-061116-1
Gene Name: forkhead box E1
Gene Symbol: foxe1    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in embryonic viscerocranium morphogenesis and growth plate cartilage chondrocyte proliferation. Predicted to localize to nucleus. Is expressed in several structures, including central nervous system; endocrine system; head; notochord; and pharynx. Human ortholog(s) of this gene implicated in Bamforth-Lazarus syndrome and thyroid gland papillary carcinoma. Orthologous to human FOXE1 (forkhead box E1).
Genome Resources: Alliance (1),  Gene:567676 (1),  Ensembl(GRCz11):ENSDARG00000079266 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32687 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39620 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-foxe1 N/A 1
    MO2-foxe1 N/A 1
    DISEASE ASSOCIATED WITH foxe1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bamforth-Lazarus syndrome Alliance Bamforth-Lazarus syndrome 241850
    {Thyroid cancer, nonmedullary, 4} 616534
    DISEASE ASSOCIATED WITH foxe1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxe1-202 (1)    Ensembl 1383
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxe1 No data available
    MARKER RELATIONSHIPS
    foxe1 Contained in: [BAC] DKEY-25O16 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005159910 (1)
    Genomic GenBank:BX005000 (1) 234373 nt Blast at MegaBLAST
    Polypeptide UniProtKB:R4GEW1 (1) 375 aa
    Sequence Information (all 7)
    ORTHOLOGY for foxe1 ( Chr: 1 )
    CITATIONS (19)