ZFIN

ZFIN ID: ZDB-GENE-051102-2

ZFIN ID: ZDB-GENE-051102-2

CITATIONS (66 total)

Gene Name:	NPHS2 stomatin family member, podocin
Gene Symbol:	nphs2

Hopfenmüller, V.L., Perner, B., Reuter, H., Bates, T.J.D., Große, A., Englert, C. (2022) The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish. Frontiers in cell and developmental biology. 9:809962

Lee, M.S., Devi, S., He, J.C., Zhou, W. (2022) A zebrafish model of congenital nephrotic syndrome of the Finnish type. Frontiers in cell and developmental biology. 10:976043

Naylor, R.W., Lemarie, E., Jackson-Crawford, A., Davenport, J.B., Mironov, A., Lowe, M., Lennon, R. (2022) A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. Kidney International. 102(4):815-827

Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47

Chu, S., Kwon, B.R., Lee, Y.M., Zoh, K.D., Choi, K. (2021) Effects of 2-ethylhexyl-4-methoxycinnamate (EHMC) on thyroid hormones and genes associated with thyroid, neurotoxic, and nephrotoxic responses in adult and larval zebrafish (Danio rerio). Chemosphere. 263:128176

Hansen, K.U.I., Siegerist, F., Daniel, S., Schindler, M., Iervolino, A., Blumenthal, A., Daniel, C., Amann, K., Zhou, W., Endlich, K., Endlich, N. (2020) Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(12):15961-15974

Schindler, M., Blumenthal, A., Moeller, M.J., Endlich, K., Endlich, N. (2020) Adriamycin does not damage podocytes of zebrafish larvae. PLoS One. 15:e0242436

Wang, X., Giusti, A., Ny, A., de Witte, P.A. (2020) Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid. toxins. 12(4):

She, J., Wu, Y., Lou, B., Lodd, E., Klems, A., Schmoehl, F., Yuan, Z., Noble, F.L., Kroll, J. (2019) Genetic compensation by epob in pronephros development in epoa mutant zebrafish. Cell cycle (Georgetown, Tex.). 18(20):2683-2696

Endlich, N., Kliewe, F., Kindt, F., Schmidt, K., Kotb, A.M., Artelt, N., Lindenmeyer, M.T., Cohen, C.D., Döring, F., Kuss, A.W., Amann, K., Moeller, M.J., Kabgani, N., Blumenthal, A., Endlich, K. (2018) The transcription factor Dach1 is essential for podocyte function. Journal of Cellular and Molecular Medicine. 22(5):2656-2669

Endlich, N., Lange, T., Kuhn, J., Klemm, P., Kotb, A.M., Siegerist, F., Kindt, F., Lindenmeyer, M.T., Cohen, C.D., Kuss, A.W., Nath, N., Rettig, R., Lendeckel, U., Zimmermann, U., Amann, K., Stracke, S., Endlich, K. (2018) BDNF: mRNA expression in urine cells of patients with chronic kidney disease and its role in kidney function. Journal of Cellular and Molecular Medicine. 22(11):5265-5277

Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178

Chou, C.W., Lin, J., Jiang, Y.J., Liu, Y.W. (2017) Aberrant global and Jagged-mediated Notch signaling disrupts segregation between wt1-expressing and steroidogenic tissues in zebrafish. Endocrinology. 158(12):4206-4217

Ito, Y., Katayama, K., Nishibori, Y., Akimoto, Y., Kudo, A., Kurayama, R., Hada, I., Takahashi, S., Kimura, T., Fukutomi, T., Katada, T., Suehiro, J., Beltcheva, O., Tryggvason, K., Yan, K. (2017) Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression. American journal of physiology. Renal physiology. 312(6):F1184-F1199

Pan, Y., Jiang, S., Hou, Q., Qiu, D., Shi, J., Wang, L., Chen, Z., Zhang, M., Duan, A., Qin, W., Zen, K., Liu, Z. (2017) Dissection of Glomerular Transcriptional Profile in Patients with Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function. Diabetes. 67(4):717-730

She, J., Yuan, Z., Wu, Y., Chen, J., Kroll, J. (2017) Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Molecular metabolism. 8:189-202

Siegerist, F., Blumenthal, A., Zhou, W., Endlich, K., Endlich, N. (2017) Acute podocyte injury is not a stimulus for podocytes to migrate along the glomerular basement membrane in zebrafish larvae. Scientific Reports. 7:43655

Sun, J., Hultenby, K., Axelsson, J., Nordström, J., He, B., Wernerson, A., Lindström, K. (2017) Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies. Kidney international reports. 2:721-732

Chen, Z., Wan, X., Hou, Q., Shi, S., Wang, L., Chen, P., Zhu, X., Zeng, C., Qin, W., Zhou, W., Liu, Z. (2016) GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway. Cell Death & Disease. 7:e2068

Kuusela, S., Wang, H., Wasik, A.A., Suleiman, H., Lehtonen, S. (2016) Tankyrase inhibition aggravates kidney injury in the absence of CD2AP. Cell Death & Disease. 7:e2302

Wan, X., Chen, Z., Choi, W.I., Gee, H.Y., Hildebrandt, F., Zhou, W. (2016) Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1. Journal of the American Society of Nephrology : JASN. 27(4):1066-75

Wan, X., Lee, M.S., Zhou, W. (2016) Dosage-dependent Role of RAC1 in Podocyte Injury. American journal of physiology. Renal physiology. 310(8):F777-F784

Anderson, B.R., Howell, D.N., Soldano, K., Garrett, M.E., Katsanis, N., Telen, M.J., Davis, E.E., Ashley-Koch, A.E. (2015) In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress. PLoS Genetics. 11:e1005349

Dong, L., Pietsch, S., Tan, Z., Perner, B., Sierig, R., Kruspe, D., Groth, M., Witzgall, R., Gröne, H., Platzer, M., Englert, C. (2015) Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. Journal of the American Society of Nephrology : JASN. 26(9):2118-28

Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11

Rodriguez, P.Q., Oddsson, A., Ebarasi, L., He, B., Hultenby, K., Wernerson, A., Betsholtz, C., Tryggvason, K., Patrakka, J. (2015) Knockdown of Tmem234 in zebrafish results in proteinuria. American journal of physiology. Renal physiology. 309(11):F955-66

Yeo, N.C., O'Meara, C.C., Bonomo, J.A., Veth, K.N., Tomar, R., Flister, M.J., Drummond, I.A., Bowden, D.W., Freedman, B.I., Lazar, J., Link, B.A., Jacob, H.J. (2015) Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity. Genome research. 25(1):57-65

Fukuyo, Y., Nakamura, T., Bubenshchikova, E., Powell, R., Tsuji, T., Janknecht, R., and Obara, T. (2014) Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Molecular Medicine Reports. 9(2):457-465

He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77

Tomar, R., Mudumana, S.P., Pathak, N., Hukreide, N.A., Drummond, I.A. (2014) osr1 Is Required for Podocyte Development Downstream of wt1a. Journal of the American Society of Nephrology : JASN. 25(11):2539-45

He, B., Osterholm, A.M., Ojala, J.R., Andersson, A.C., and Tryggvason, K. (2013) A Remote Cis-Acting Variant at 3q Links Glomerular NCK1 to Diabetic Nephropathy. PLoS One. 8(2):e56414

Huang, C.J., Wilson, V., Pennings, S., MacRae, C.A., and Mullins, J. (2013) Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Developmental Biology. 384(2):290-300

Huang, J., McKee, M., Huang, H.D., Xiang, A., Davidson, A.J., and Lu, H.A. (2013) A zebrafish model of conditional targeted podocyte ablation and regeneration. Kidney International. 83(6):1193-200

Naylor, R.W., Przepiorski, A., Ren, Q., Yu, J., and Davidson, A.J. (2013) HNF1beta Is Essential for Nephron Segmentation during Nephrogenesis. Journal of the American Society of Nephrology : JASN. 24(1):77-87

Bedell, V.M., Person, A.D., Larson, J.D., McLoon, A., Balciunas, D., Clark, K.J., Neff, K.I., Nelson, K.E., Bill, B.R., Schimmenti, L.A., Beiraghi, S., and Ekker, S.C. (2012) The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development. Development (Cambridge, England). 139(4):793-804

Mitra, S., Lukianov, S., Ruiz, W.G., Cianciolo Cosentino, C., Sanker, S., Traub, L.M., Hukriede, N.A., and Apodaca, G. (2012) Requirement for a uroplakin 3a-like protein in the development of zebrafish pronephric tubule epithelial cell function, morphogenesis, and polarity. PLoS One. 7(7):e41816

Wang, H., Lehtonen, S., Chen, Y.C., Heikkilä, E., Panula, P., and Holthöfer, H. (2012) Neph3 associates with regulation of glomerular and neural development in zebrafish. Differentiation; research in biological diversity. 83(1):38-46

Chen, Q., Huang, S., Zhao, Q., Chen, R., and Zhang, A. (2011) Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros. Pediatric nephrology (Berlin, Germany). 26(3):391-400

He, B., Ebarasi, L., Hultenby, K., Tryggvason, K., and Betsholtz, C. (2011) Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes. Journal of the American Society of Nephrology : JASN. 22(6):1019-1023

O'Brien, L.L., Grimaldi, M., Kostun, Z., Wingert, R.A., Selleck, R., and Davidson, A.J. (2011) Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Developmental Biology. 358(2):318-30

Zhou, W., Boucher, R.C., Bollig, F., Englert, C., and Hildebrandt, F. (2010) Characterization of Mesonephric Development and Regeneration Using Transgenic Zebrafish. American journal of physiology. Renal physiology. 299(5):F1040-F1047

Ebarasi, L., He, L., Hultenby, K., Takemoto, M., Betsholtz, C., Tryggvason, K., and Majumdar, A. (2009) A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier. Developmental Biology. 334(1):1-9

Hentschel, D.M., Mengel, M., Boehme, L., Liebsch, F., Albertin, C., Bonventre, J.V., Haller, H., and Schiffer, M. (2007) Rapid screening of glomerular slit diaphragm integrity in larval zebrafish. American journal of physiology. Renal physiology. 293(5):F1746-F1750

Hoshijima, K., and Hirose, S. (2007) Expression of endocrine genes in zebrafish larvae in response to environmental salinity. The Journal of endocrinology. 193(3):481-491

Perner, B., Englert, C., and Bollig, F. (2007) The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Developmental Biology. 309(1):87-96

Kramer-Zucker, A.G., Wiessner, S., Jensen, A.M., and Drummond, I.A. (2005) Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Developmental Biology. 285(2):316-329

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (19):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.