ZFIN

ZFIN ID: ZDB-GENE-000509-3

ZFIN ID: ZDB-GENE-000509-3

CITATIONS (52 total)

Gene Name:	SMAD family member 3a
Gene Symbol:	smad3a

Sheppard, M.B., Smith, J.D., Bergmann, L.L., Famulski, J.K. (2023) Novel SMAD3 variant identified in a patient with familial aortopathy modeled using a zebrafish embryo assay. Frontiers in cardiovascular medicine. 10:11037841103784

Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., Papaleonidopoulou, F., Barrington, C., East, P., Economou, A.D., French, P.M.W., McGinty, J., Hill, C.S. (2021) Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nature communications. 12:6374

Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:632372

Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387

Sloin, H.E., Ruggiero, G., Rubinstein, A., Smadja Storz, S., Foulkes, N.S., Gothilf, Y. (2018) Interactions between the circadian clock and TGF-β signaling pathway in zebrafish. PLoS One. 13:e0199777

Bian, S.S., Zheng, X.L., Sun, H.Q., Chen, J.H., Lu, Y.L., Liu, Y.Q., Tao, D.C., Ma, Y.X. (2017) Clock1a affects mesoderm development and primitive hematopoiesis by regulating Nodal-Smad3 signalings in the zebrafish embryo. The Journal of biological chemistry. 292(34):14165-14175

Liu, J.X., Xu, Q.H., Li, S., Yu, X., Liu, W., Ouyang, G., Zhang, T., Chen, L.L. (2017) Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-β signaling. Biochimica et biophysica acta. 1860(10):1103-1116

Dai, Y., Prithiviraj, N., Gan, J., Zhang, X.A., Yan, J. (2016) Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish. Scientific Reports. 6:38693

Flanagan-Steet, H., Aarnio, M., Kwan, B., Guihard, P., Petrey, A., Haskins, M., Blanchard, F., Steet, R. (2016) Cathepsin-Mediated Alterations In TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 31(3):535-48

Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70

Peng, X., Li, G., Wang, Y., Zhuang, J., Luo, R., Chen, J., Chen, F., Shi, Y., Li, J., Zhou, Z., Mo, X., Liu, X., Yuan, W., Zeng, Q., Li, Y., Jiang, Z., Wan, Y., Ye, X., Xu, W., Wang, X., Fan, X., Zhu, P., Wu, X., Deng, Y. (2016) CXXC5 is required for cardiac looping relating to TGFβ signaling pathway in zebrafish. International Journal of Cardiology. 214:246-253

Samarut, E., Bekri, A., Drapeau, P. (2016) Transcriptomic Analysis of Purified Embryonic Neural Stem Cells from Zebrafish Embryos Reveals Signaling Pathways Involved in Glycine-Dependent Neurogenesis. Frontiers in molecular neuroscience. 9:22

Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

Casari, A., Schiavone, M., Facchinello, N., Vettori, A., Meyer, D., Tiso, N., Moro, E., Argenton, F. (2014) A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Developmental Biology. 396(1):81-93

Sun, Y., Tseng, W.C., Fan, X., Ball, R., and Dougan, S.T. (2014) Extraembryonic signals under the control of MGA, Max, and Smad4 are required for dorsoventral patterning. Developmental Cell. 28(3):322-334

Li, Y., Li, G., Wang, H., Du, J., and Yan, J. (2013) Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish. PLoS Computational Biology. 9(2):e1002940

Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nature communications. 4:1728

Miyares, R.L., Stein, C., Renisch, B., Anderson, J.L., Hammerschmidt, M., and Farber, S.A. (2013) Long-Chain Acyl-CoA Synthetase 4A Regulates Smad Activity and Dorsoventral Patterning in the Zebrafish Embryo. Developmental Cell. 27(6):635-647

Saili, K.S., Tilton, S.C., Waters, K.M., and Tanguay, R.L. (2013) Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17beta-estradiol in embryonic zebrafish. Reproductive toxicology (Elmsford, N.Y.). 38:89-101

Jayasena, C.S., and Bronner, M.E. (2012) Rbms3 functions in craniofacial development by posttranscriptionally modulating TGF-β signaling. The Journal of cell biology. 199(3):453-466

Liongue, C., O'Sullivan. L.A., Trengove, M.C., and Ward, A.C. (2012) Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One. 7(3):e32777

Liu, W., Chen, J.R., Hsu, C.H., Li, Y.H., Chen, Y.M., Lin, C.Y., Huang, S.J., Chang, Z.K., Chen, Y.C., Lin, C.H., Gong, H.Y., Lin, C.C., Kawakami, K., and Wu, J.L. (2012) A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. Hepatology (Baltimore, Md.). 56(6):2268-2276

Hsu, R.J., Lin, C.C., Su, Y.F., and Tsai, H.J. (2011) dickkopf-3-related Gene Regulates the Expression of Zebrafish myf5 Gene through Phosphorylated p38a-dependent Smad4 Activity. The Journal of biological chemistry. 286(8):6855-6864

Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32

Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009

Jia, S., Ren, Z., Li, X., Zheng, Y., and Meng, A. (2008) smad2 and smad3 Are Required for Mesendoderm Induction by Transforming Growth Factor-β/Nodal Signals in Zebrafish. The Journal of biological chemistry. 283(4):2418-2426

Xiong, B., Rui, Y., Zhang, M., Shi, K., Jia, S., Tian, T., Yin, K., Huang, H., Lin, S., Zhao, X., Chen, Y., Chen, Y.G., Lin, S.C., and Meng, A. (2006) Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Developmental Cell. 11(2):225-238

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Dick, A., Mayr, T., Bauer, H., Meier, A., and Hammerschmidt, M. (2000) Cloning and characterization of zebrafish smad2, smad3 and smad4. Gene. 246(1-2):69-80

Additional Citations (22):

Zebrafish Nomenclature Committee (2023) Nomenclature Data Curation (2023). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2016) Automated addition of links from ZFIN gene pages to SignaFish. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.