ZFIN ID: ZDB-GENE-000509-3
Gene Name: SMAD family member 3a
Gene Symbol: smad3a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: madh3a, smad3 (1), wu:fa99e03

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in mesoderm development; primitive hemopoiesis; and regulation of transcription, DNA-templated. Predicted to localize to cytoplasm; nucleus; and transcription regulator complex. Is expressed in immature eye; integument; somite; and tail bud. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic cancer. Orthologous to human SMAD3 (SMAD family member 3).
Genome Resources: Alliance (1),  Gene:58092 (1),  Ensembl(GRCz11):ENSDARG00000036096 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2363 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34112 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smad3a N/A 3
    MO2-smad3a N/A 1
    DISEASE ASSOCIATED WITH smad3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Loeys-Dietz syndrome 3 Alliance Loeys-Dietz syndrome 3 613795
    DISEASE ASSOCIATED WITH smad3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smad3a-201 (1)    Ensembl 6173
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smad3a No data available
    MARKER RELATIONSHIPS
    smad3a Contained in: [BAC] DKEY-34G19 (1) (order this)
    smad3a Encodes: [EST] fa99e03
    [cDNA] MGC:158174 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131571 (1) 2702 nt
    Genomic GenBank:CR927368 180874 nt
    Select Tool
    Polypeptide UniProtKB:Q8AY15 (1) 425 aa
    Sequence Information (all 16)
    ORTHOLOGY for smad3a ( Chr: 7 )
    CITATIONS (46)