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ZIRC
ZFIN ID: ZDB-EXP-191112-3
Experiment Conditions Description: chemical treatment by environment: GI254023X, amputation: caudal fin
chemical treatment by environment: GI254023X
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: GI254023X
Synonyms: (2R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide, (2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl]amide, GI-254023X, GI-4023, GI4023, N(2)-[(2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamide
Definition: A L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively.
Ontology: Chebi [CHEBI:143102]
amputation: caudal fin
Name: amputation
Synonyms:
Definition: Resection condtion in which all or part of an extremity such as the fin or tail are removed.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000172]
Name: caudal fin
Synonyms: tail, tail fin
Definition: Fin that is the most posterior median fin. It is composed of a complex of three modified centra and modified neural and hemal arches and spines.
Ontology: Anatomy Ontology [ZFA:0001058]
Publication: Baek et al., 2017