GI254023X

Term ID

CHEBI:143102

Synonyms

(2R)-N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide
(2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl]amide
GI-254023X
GI-4023
GI4023
N(2)-[(2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamide

Definition

A L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aldehyde hydroxylamines L-valine derivative

aldehyde hydroxylamines L-valine derivative Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 3.4.24.* (metalloendopeptidase) inhibitor matrix metalloproteinase inhibitor

antineoplastic agent apoptosis inducer EC 3.4.24.* (metalloendopeptidase) inhibitor matrix metalloproteinase inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from GI254023X

Phenotype where environments contain GI254023X

Phenotype modified by environments containing GI254023X

Human Disease / Model Data

Citations