Gene

dis3l2

ID
ZDB-GENE-070705-171
Name
DIS3 like 3'-5' exoribonuclease 2
Symbol
dis3l2 Nomenclature History
Previous Names
  • si:ch211-273k1.4
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable 3'-5'-exoribonuclease activity. Acts upstream of or within pronephros development. Predicted to be located in cytoplasm. Predicted to be part of exosome (RNase complex). Predicted to be active in P-body. Is expressed in pronephros. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Astuti et al., 2012
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Astuti et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dis3l2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Perlman syndrome Alliance Perlman syndrome 267000
Associated With dis3l2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022966 Ribonuclease II/R, conserved site
Domain IPR001900 Ribonuclease II/R
Domain IPR033771 Rrp44-like cold shock domain
Domain IPR041093 DIS3-like exonuclease 2, C-terminal
Domain IPR041505 Dis3-like cold-shock domain 2
Family IPR028591 DIS3-like exonuclease 2
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Domain Details Per Protein
Protein Length Dis3-like cold-shock domain 2 DIS3-like exonuclease 2 DIS3-like exonuclease 2, C-terminal Nucleic acid-binding, OB-fold Ribonuclease II/R Ribonuclease II/R, conserved site Rrp44-like cold shock domain
UniProtKB:E7F350 995
UniProtKB:A0A2R8Q8H5 978
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations