Gene

ctnna2

ID
ZDB-GENE-060815-3
Name
catenin (cadherin-associated protein), alpha 2
Symbol
ctnna2 Nomenclature History
Previous Names
  • im:5410539
  • si:rp71-1h10.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; cadherin binding activity; and structural molecule activity. Predicted to be involved in several processes, including brain morphogenesis; neuron projection morphogenesis; and regulation of synapse structural plasticity. Predicted to localize to adherens junction; axon; and cytoplasm. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Is expressed in female organism. Orthologous to human CTNNA2 (catenin alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctnna2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cortical dysplasia, complex, with other brain malformations 9 618174
Associated With ctnna2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000633 Vinculin, conserved site
Family IPR001033 Alpha-catenin
Family IPR006077 Vinculin/alpha-catenin
Family IPR030046 Alpha N-catenin
Family IPR030047 Alpha E-catenin/Alpha T-catenin
Homologous_superfamily IPR036723 Alpha-catenin/vinculin-like superfamily
Domain Details Per Protein
Protein Length Alpha-catenin Alpha-catenin/vinculin-like superfamily Alpha E-catenin/Alpha T-catenin Alpha N-catenin Vinculin/alpha-catenin Vinculin, conserved site
UniProtKB:B7ZC77
UniProtKB:A0A286Y8G3 380
UniProtKB:Q4V9D9 359
UniProtKB:X1WG13 521
UniProtKB:A0A2R8QSE5 367
UniProtKB:Q5XJV0 359
UniProtKB:F1Q548 373
UniProtKB:B8A6A9 430
UniProtKB:B8JKG9 271
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations