Gene

comp

ID
ZDB-GENE-060606-1
Name
cartilage oligomeric matrix protein
Symbol
comp Nomenclature History
Previous Names
  • im:7154332
  • thbs5 (1)
  • thrombospondin 5 (1)
  • Tsp-4b (1)
  • wu:fb78h09
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to localize to extracellular region. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Is expressed in several structures, including head mesenchyme; heart primordium; mesoderm; pectoral fin; and somite. Orthologous to human COMP (cartilage oligomeric matrix protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With comp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple epiphyseal dysplasia 1 Alliance Epiphyseal dysplasia, multiple, 1 132400
pseudoachondroplasia Alliance Pseudoachondroplasia 177170
Carpal tunnel syndrome 2 619161
Associated With comp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR008859 Thrombospondin, C-terminal
Domain IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
Domain IPR039081 Thrombospondin-5, coiled coil region
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR028974 TSP type-3 repeat
Repeat IPR003367 Thrombospondin, type 3-like repeat
Repeat IPR017897 Thrombospondin, type 3 repeat
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain Thrombospondin-5, coiled coil region Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain Thrombospondin, C-terminal Thrombospondin, type 3-like repeat Thrombospondin, type 3 repeat TSP type-3 repeat
UniProtKB:A0A0G2KDJ5 749
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations