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Gene

dot1l

ID
ZDB-GENE-060503-341
Name
DOT1-like histone H3K79 methyltransferase
Symbol
dot1l Nomenclature History
Previous Names
  • si:dkey-211f22.1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable histone methyltransferase activity (H3-K79 specific). Acts upstream of or within canonical Wnt signaling pathway and intestinal epithelial structure maintenance. Predicted to be active in nucleus. Is expressed in hindbrain; intestine; and midbrain. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Mahmoudi et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dot1l Human Ortholog
No data available
Associated With dot1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR025789 Histone-lysine N-methyltransferase DOT1 domain
Family IPR030445 Histone H3-K79 methyltransferase
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length Histone H3-K79 methyltransferase Histone-lysine N-methyltransferase DOT1 domain S-adenosyl-L-methionine-dependent methyltransferase
UniProtKB:A8E7B7 1122
UniProtKB:A0A2R8QAW0 1365
UniProtKB:A0A2R8QPA8 1307
UniProtKB:F1Q4W7 1454
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations