ZFIN is now using GRCz12tu for Genomic Data
Gene
dock11
- ID
- ZDB-GENE-060503-196
- Name
- dedicator of cytokinesis 11
- Symbol
- dock11 Nomenclature History
- Previous Names
-
- si:ch211-150g2.3
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of filopodium assembly and regulation of Rho protein signal transduction. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human DOCK11 (dedicator of cytokinesis 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoinflammatory disease, multisystem, with immune dysregulation, X-linked | 301109 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR021816 | Dedicator of cytokinesis C/D, N-terminal |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR037809 | Dedicator of cytokinesis D, C2 domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis C/D, N-terminal | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis D, C2 domain | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q1V0 | InterPro | 2041 | |||||||||||||
| UniProtKB:B0R034 | InterPro | 2067 | |||||||||||||
| UniProtKB:A0A0R4ILW7 | InterPro | 2057 | |||||||||||||
| UniProtKB:A0A8M9PP60 | InterPro | 2054 | |||||||||||||
| UniProtKB:A0AC58G0P4 | InterPro | 2054 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dock11-201
(1)
|
Ensembl | 6,209 nt | ||
| mRNA |
dock11-202
(1)
|
Ensembl | 9,964 nt | ||
| mRNA |
dock11-203
(1)
|
Ensembl | 9,806 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers