Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish
- Nikaido, M., Tada, M., and Ueno, N.
- Mechanisms of Development 82(1-2): 219-222 (Journal)
- Registered Authors
- Nikaido, Masataka, Tada, Masazumi, Ueno, Naoto
- zebrafish; BMP; BMP receptor; somite; CNS
- MeSH Terms
- Amino Acid Sequence
- Bone Morphogenetic Protein Receptors, Type I
- Cloning, Molecular
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Enzymologic
- In Situ Hybridization
- Molecular Sequence Data
- Protein Serine-Threonine Kinases/genetics*
- Receptors, Growth Factor/genetics*
- 10354489 Full text @ Mech. Dev.
Nikaido, M., Tada, M., and Ueno, N. (1999) Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish. Mechanisms of Development. 82(1-2):219-222.
Bone morphogenetic proteins (BMPs) comprise a rapidly expanding subclass of the transforming growth factor-beta superfamily. They are known to regulate a diverse range of developmental phenomena including cell differentiation, morphogenesis and apoptosis. In this study, we have isolated a zebrafish homolog of BMP type IB receptor (BMPR-IB) and examined the localization of the transcripts during embryogenesis. Whole-mount in situ hybridization analysis revealed that unlike other type I and type II receptors that mediate BMP signal, it is expressed in developing somite and in mid-hind brain region in a restricted manner.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes