Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1
- Warren, J.T., Jr., Chandrasekhar, A., Kanki, J.P., Rangarajan, R., Furley, A.J., and Kuwada, J.Y.
- Mechanisms of Development 80(2): 197-201 (Journal)
- Registered Authors
- Chandrasekhar, Anand, Kanki, John, Kuwada, John, Warren, James T., Jr.
- zebrafish; axon pathfinding; brain; cell adhesion molecule; glycoprotein; growth cone; tag1; gene expression; neuronal development; branchiomotor neuron; eye; neural crest; spinal cord; lateral line; trigeminal ganglion
- MeSH Terms
- Cell Adhesion Molecules, Neuronal*
- Central Nervous System/embryology*
- Central Nervous System/metabolism
- Cloning, Molecular
- Contactin 2
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/ultrastructure
- Gene Expression Regulation, Developmental*
- In Situ Hybridization
- Membrane Glycoproteins/biosynthesis
- Membrane Glycoproteins/genetics*
- Membrane Glycoproteins/physiology
- Sequence Homology, Amino Acid
- 10072788 Full text @ Mech. Dev.
Warren, J.T., Jr., Chandrasekhar, A., Kanki, J.P., Rangarajan, R., Furley, A.J., and Kuwada, J.Y. (1999) Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1. Mechanisms of Development. 80(2):197-201.
TAG-1 is a mammalian cell adhesion molecule of the immunoglobulin superfamily that is expressed transiently by a subset of neurons and serves as a fertile substrate for neurite outgrowth in vitro (Furley, A.H., Morton, S.B., Manalo, D., Karagogeos, S., Dodd, H., Jessell, T.M., 1990 The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth promoting activity. Cell 61, 157-170). In order to examine the in vivo function of this molecule, we have cloned a zebrafish tag1-like cDNA and analyzed its expression patterns. tag1 Is expressed transiently by specific subsets of neurons when they are projecting their axons or when they are migrating. The specific and dynamic pattern of expression of zebrafish tag1 is consistent with its proposed role in axon guidance and cell migration.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes