|ZFIN ID: ZDB-PUB-990107-8|
Function of zebrafish ß-catenin and TCF-3 in dorsoventral patterning
Pelegri, F. and Maischein, H.M.
|Source:||Mechanisms of Development 77: 63-74 (Journal)|
|Registered Authors:||Maischein, Hans-Martin, Pelegri, Francisco|
|Keywords:||Amino Acid Sequence; Animal; Binding Sites; Body Patterning; Cloning, Molecular; Cytoskeletal Proteins; Embryo, Nonmammalian; Gastrula; Gene Expression Regulation, Developmental; Genes, Structural; Homeodomain Proteins; Molecular Sequence Data; Mutation; Sequence Homology, Amino Acid; Support, Non-U.S. Gov't; Transcription Factors; Zebrafish|
|PubMed:||9784608 Full text @ Mech. Dev.|
Pelegri, F. and Maischein, H.M. (1998) Function of zebrafish ß-catenin and TCF-3 in dorsoventral patterning. Mechanisms of Development. 77:63-74.
ABSTRACTWe report the molecular cloning and expression of the zebrafish tcf-3 homologue and study its function and that of zebrafish betacat in dorsoventral patterning. Overexpression of mutant zTcf-3 products and Cadherin leads to a reduction in the expression of the dorsal-specific genes goosecoid and chording at the blastula stages, indicating a conserved role for betacat and tcf-3 in zebrafish dorsal axis induction. Later during gastrulation, overexpression of these same products leads to the ectopic expression of dorsal-specific genes in the marginal zone and the induction of ectopic axes, suggesting an additional role for betacat and Tcf-3 at these later stages in the repression of dorsal fates.