|ZFIN ID: ZDB-PUB-980210-48|
A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation
Li, L. and Dowling, J.E.
|Source:||Proceedings of the National Academy of Sciences of the United States of America 94: 11645-11650 (Journal)|
|Registered Authors:||Dowling, John E., Li, Lei|
|PubMed:||9326664 Full text @ Proc. Natl. Acad. Sci. USA|
Li, L. and Dowling, J.E. (1997) A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. Proceedings of the National Academy of Sciences of the United States of America. 94:11645-11650.
ABSTRACTWe have isolated a dominant mutation, night blindness a (nba), that causes a slow retinal degeneration in zebrafish. Heterozygous nba fish have normal vision through 2-3 months of age but subsequently become night blind. By 9.5 months of age, visual sensitivity of affected fish may be decreased more than two log units, or 100-fold, as measured behaviorally. Electroretinographic (ERG) thresholds of mutant fish are also raised significantly, and the ERG b-wave shows a delayed implicit time. These defects are due primarily to a late-onset photoreceptor cell degeneration involving initially the rods but eventually the cones as well. Homozygous nba fish display an early-onset neuronal degeneration throughout the retina and elsewhere in the central nervous system. As a result, animals develop with small eyes and die by 4-5 days postfertilization (pf). These latter data indicate that the mutation affecting nba fish is not in a photoreceptor cell-specific gene.