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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-333
Li, Lei
Email: lei.li.78@nd.edu
URL: http://biology.nd.edu/people/lei-li/
Affiliation: Lei Li Lab
Address: Department of Biological Sciences University of Notre Dame 107 Galvin Life Science Building Notre Dame, IN 46556 USA
Country: United States
Phone: (574) 631-7488
Fax: (574) 631-7413
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
The primary interests of our research are to understand the molecular genetic basis of dominant visual system disorders in zebrafish and the role of intrinsic factors shch as circadian oscillators and olfactory centrifugal fibers in the regulation of zebrafish visual sensitivity. Multidisciplinary approaches including molecualr and cellular, behavioral, and electrophysiological techniques are employed in our laboratory.


PUBLICATIONS
Li, L., Liu, C., Carr, A.L. (2019) STIL: a multi-function protein required for dopaminergic neural proliferation, protection, and regeneration. Cell death discovery. 5:90
Li, L. (2019) Sensory Integration: Cross-Modal Communication Between the Olfactory and Visual Systems in Zebrafish. Chemical senses. 44(6):351-356
Banerjee, S., Scheirer, W.J., Li, L. (2019) An Extreme Value Theory Model of Cross-Modal Sensory Information Integration in Modulation of Vertebrate Visual System Functions. Frontiers in computational neuroscience. 13:3
Li, L., Wojtowicz, J.L., Malin, J.H., Huang, T., Lee, E.B., Chen, Z. (2017) GnRH-mediated olfactory and visual inputs promote mating-like behaviors in male zebrafish. PLoS One. 12:e0174143
Ma, H., Lin, Y., Zhao, Z.A., Lu, X., Yu, Y., Zhang, X., Wang, Q., Li, L. (2016) MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-Right Determination Factor 2. The Journal of biological chemistry. 291:12126-35
Li, L., Sahi, S.K., Peng, M., Lee, E.B., Ma, L., Wojtowicz, J.L., Malin, J.H., Chen, W. (2016) Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light. Scientific Reports. 6:20821
Pfister, D., Yu, C., Kim, D.S., Li, J., Drewing, A., Li, L. (2016) Zebrafish Olfacto-Retinal Centrifugal Axon Projection and Distribution: Effects of Gonadotropin-Releasing Hormone and Dopaminergic Signaling. Developmental neuroscience. 38(1):27-33
Zhao, S.S., Wang, Y.L., Sun, M.Z., Lu, L., Wang, Y.N., Pfister, D., Lee, J., Zhao, X., Feng, X.Z., Li, L. (2015) Drug screening: zebrafish as a tool for studying epileptic-related chemical compounds. Protein & cell. 6(11):853-7
Li, G., Li, L., Zhu, L., Xia, J., Wang, L.V. (2015) Multiview Hilbert transformation for full-view photoacoustic computed tomography using a linear array. Journal of Biomedical Optics. 20:066010
Sun, L., Carr, A.L., Li, P., Lee, J., McGregor, M., Li, L. (2014) Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons. Biochemical and Biophysical Research Communications. 449(4):444-8
Su, Z., Si, W., Li, L., Zhou, B., Li, X., Xu, Y., Xu, C., Jia, H., and Wang, Q.K. (2014) MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development. The international journal of biochemistry & cell biology. 49:53-63
Sun, L., Li, P., Carr, A.L., Gorsuch, R., Yarka, C., Li, J., Bartlett, M., Pfister, D., Hyde, D.R., and Li, L. (2014) Transcription of the SCL/TAL1 interrupting locus (Stil) is required for cell proliferation in adult zebrafish retinas. The Journal of biological chemistry. 289(10):6934-40
Li, L., Chen, D., Li, J., Wang, X., Wang, N., Xu, C., and Wang, Q.K. (2014) Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish. Blood. 123(4):501-8
Xi, Y., Chen, D., Sun, L., Li, Y., and Li, L. (2013) Characterization of zebrafish mutants with defects in bone calcification during development. Biochemical and Biophysical Research Communications. 440(1):132-136
Chen, D., Li, L., Tu, X., Yin, Z., and Wang, Q. (2013) Functional characterization of Klippel-Trenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation during embryogenesis. Human molecular genetics. 22(5):963-976
Li, J., Li, P., Carr, A., Wang, X., Delapaz, A., Sun, L., Lee, E., Tomei, E., and Li, L. (2013) Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration. The Journal of biological chemistry. 288(2):886-893
Ye, Q., Chen, D., Xi, Y., Li, J., Shao, J., and Li, L. (2012) Effects of light illumination and the expression of wee1 on tissue regeneration in adult zebrafish. Biochemical and Biophysical Research Communications. 428(1):132-136
Huang, T., Cui, J., Li, L., Hitchcock, P.F., and Li, Y. (2012) The role of microglia in the neurogenesis of zebrafish retina. Biochemical and Biophysical Research Communications. 421(2):214-220
Li, X., Montgomery, J., Cheng, W., Noh, J.H., Hyde, D.R., and Li, L. (2012) Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish. PLoS One. 7(7):e40508
Liu, Y., Wu, Y., Feng, D., Ye, Q., Yang, X., Liu, X., Gao, C., Wu, M., Chen, D., Zhang, Y., Li, L., and Feng, X. (2011) Optical tracking and biocompatibility assessment of nanoparticles from triblock copolymer encapsulating-dye complexes. Journal of Materials Chemistry. 21:18704-18710
Shao, J., Chen, D., Ye, Q., Cui, J., Li, Y., and Li, L.. (2011) Tissue regeneration after injury in adult zebrafish: The regenerative potential of the caudal fin. Developmental dynamics : an official publication of the American Association of Anatomists. 240(5):1271-1277
Wang, X., Huang, L., Li, Y., Li, X., Li, P., Ray, J., and Li, L. (2011) Characterization of GFP-tagged GnRH-containing terminalis neurons in transgenic zebrafish. Journal of Cellular Physiology. 226(3):608-615
Yao, Y., Feng, D.F., Wu, Y.P., Ye, Q.J., Liu, L., Li, X.X., Hou, S., Yang, Y.L., Wang, C., Li, L., and Feng, X.Z. (2011) Influence of block sequences in polymer vectors for gene transfection in vitro and toxicity assessment of zebrafish embryos in vivo. Journal of Materials Chemistry. 21:4538-4545
Huang, L., and Li, L. (2011) Characterization of voltage-activated ionic currents in the GnRH-containing terminalis nerve in transgenic zebrafish. Brain research. 1367:43-49
Tong, Z., Li, L., Pawar, R., and Zhang, S. (2010) Vitellogenin is an acute phase protein with bacterial-binding and inhibiting activities. Immunobiology. 215(11):898-902
Li, L., Li, Y., Chen, D., Shao, J., Li, X., and Xu, C. (2010) Fishing for age-related visual system mutants: behavioral screening of retinal degeneration genes in zebrafish. Current aging science. 3(1):43-45
Wang, Z., Zhang, S., Tong, Z., Li, L., and Wang, G. (2009) Maternal transfer and protective role of the alternative complement components in zebrafish Danio rerio. PLoS One. 4(2):e4498
Li, P., Chaurasia, S.S., Gao, Y., Carr, A.L., Iuvone, P.M., and Li, L. (2008) CLOCK is required for maintaining the circadian rhythms of opsin mRNA expression in photoreceptor cells. The Journal of biological chemistry. 283(46):31673-31678
Sherpa, T., Fimbel, S.M., Mallory, D.E., Maaswinkel, H., Spritzer, S.D., Sand, J.A., Li, L., Hyde, D.R., and Stenkamp, D.L. (2008) Ganglion cell regeneration following whole-retina destruction in zebrafish. Developmental Neurobiology. 68(2):166-181
Yu, C.J., Gao, Y., Willis, C.L., Li, P., Tiano, J.P., Nakamura, P.A., Hyde, D.R., and Li, L. (2007) Mitogen-associated protein kinase- and protein kinase A-dependent regulation of rhodopsin promoter expression in zebrafish rod photoreceptor cells. Journal of neuroscience research. 85(3):488-496
Yu, C.J., Gao, Y., Li, P., and Li, L. (2007) Synchronizing multiphasic circadian rhythms of rhodopsin promoter expression in rod photoreceptor cells. The Journal of experimental biology. 210(4):676-684
Fan, C., Zhang, S., Liu, Z., Li, L., Luan, J., and Saren, G. (2007) Identification and expression of a novel class of glutathione-S-transferase from amphioxus Branchiostoma belcheri with implications to the origin of vertebrate liver. The international journal of biochemistry & cell biology. 32(2):450-461
Huang, L., and Li, L. (2006) Differential expression of voltage-activated calcium currents in zebrafish retinal ganglion cells. Journal of neuroscience research. 84(3):497-504
Huang, L., Maaswinkel, H., and Li, L. (2005) Olfactoretinal centrifugal input modulates zebrafish retinal ganglion cell activity: A possible role for dopamine-mediated Ca2+ signaling pathways. The Journal of physiology. 569(3):939-948
Yu, C.J., and Li, L. (2005) Dopamine modulates voltage-activated potassium currents in zebrafish retinal on bipolar cells. Journal of neuroscience research. 82(3):368-376
Maaswinkel, H., Riesbeck, L.E., Riley, M.E., Carr, A.L., Mullin, J.P., Nakamoto, A.T., and Li, L. (2005) Behavioral screening for nightblindness mutants in zebrafish reveals three new loci that cause dominant photoreceptor cell degeneration. Mechanisms of ageing and development. 126(10):1079-1089
Gao, Y., Li, P., and Li, L. (2005) Transgenic zebrafish that express tyrosine hydroxylase promoter in inner retinal cells. Developmental dynamics : an official publication of the American Association of Anatomists. 233(3):921-929
Li, P., Temple, S., Gao, Y., Haimberger, T.J., Hawryshyn, C.W., and Li, L. (2005) Circadian rhythms of behavioral cone sensitivity and long wavelength opsin mRNA expression: a correlation study in zebrafish. The Journal of experimental biology. 208(Pt3):497-504
Ren, J.Q. and Li, L. (2004) Rod and cone signaling transmission in the retina of zebrafish: an ERG study. The International journal of neuroscience. 114(2):259-270
Ren, J.Q., and Li, L. (2004) A circadian clock regulates the process of ERG b- and d-wave dominance transition in dark-adapted zebrafish. Vision Research. 44(18):2147-2152
Maaswinkel, H., Mason, B., and Li, L. (2003) ENU-induced late-onset night blindness associated with rod photoreceptor cell degeneration in zebrafish. Mechanisms of ageing and development. 124(10-12):1065-1071
Maaswinkel, H., Ren, J.Q., and Li, L. (2003) Slow-progressing photoreceptor cell degeneration in night blindness c mutant zebrafish. Journal of neurocytology. 32(9):1107-1116
Maaswinkel, H. and Li, L. (2003) Olfactory input increases visual sensitivity in zebrafish: a possible function for the terminal nerve and dopaminergic interplexiform cells. The Journal of experimental biology. 206(13):2201-2209
Maaswinkel, H. and Li, L. (2003) Spatio-temporal frequency characteristics of the optomotor response in zebrafish. Vision Research. 43(1):21-30
Ren, J.Q., McCarthy, W.R., Zhang, H., Adolph, A.R., and Li, L. (2002) Behavioral visual responses of wild-type and hypopigmented zebrafish. Vision Research. 42(3):293-299
Li, L. (2001) Zebrafish mutants: Behavioral genetic studies of visual system defects. Developmental dynamics : an official publication of the American Association of Anatomists. 221(4):365-372
Li, L. (2001) Genetic and epigenetic analysis of visual system functions of zebrafish. Progress in brain research. 131:555-563
Li, L. and Dowling, J.E. (2000) Effects of dopamine depletion on visual sensitivity of zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(5):1893-903
Li, L. and Dowling, J.E. (2000) Disruption of the olfactoretinal centrifugal pathway may relate to the visual system defect in night blindness b mutant zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(5):1883-1892
Li, L. and Dowling, J.E. (1998) Zebrafish visual sensitivity is regulated by a circadian clock. Visual neuroscience. 15:851-857
Li, L. and Dowling, J.E. (1997) A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation. Proceedings of the National Academy of Sciences of the United States of America. 94:11645-11650

NON-ZEBRAFISH PUBLICATIONS