PUBLICATION
Asynchronous onset of odorant receptor expression in the developing zebrafish olfactory system
- Authors
- Barth, A.L., Justice, N.J., and Ngai, J.
- ID
- ZDB-PUB-961014-75
- Date
- 1996
- Source
- Neuron 16: 23-34 (Journal)
- Registered Authors
- Barth, Alison, Ngai, John
- Keywords
- none
- MeSH Terms
-
- Olfactory Mucosa/embryology
- Olfactory Mucosa/metabolism
- Epithelium/embryology
- Epithelium/metabolism
- Olfactory Receptor Neurons/metabolism
- Molecular Sequence Data
- Amino Acid Sequence
- Binding, Competitive
- Age Factors
- Zebrafish/embryology*
- Zebrafish/growth & development
- Gene Expression Regulation, Developmental*
- Animals
- In Situ Hybridization
- Multigene Family
- Morphogenesis
- Receptors, Odorant/biosynthesis*
- Receptors, Odorant/classification
- Receptors, Odorant/genetics
- Polymerase Chain Reaction
- Transcription, Genetic
- Olfactory Pathways/embryology*
- Olfactory Pathways/growth & development
- PubMed
- 8562087 Full text @ Neuron
Citation
Barth, A.L., Justice, N.J., and Ngai, J. (1996) Asynchronous onset of odorant receptor expression in the developing zebrafish olfactory system. Neuron. 16:23-34.
Abstract
The functional identity of an olfactory neuron is determined in large part by the odorant receptors it expresses. As an approach toward understanding the events that underlie the specification of olfactory neurons, we have examined the patterns of odorant receptor gene expression in the developing zebrafish. Surprisingly, we find that the onset of specific odorant receptor expression occurs asynchronously in the developing olfactory placode. Our results suggest that odorant receptor expression is not strictly stochastic, but rather is governed by temporally regulated cues during development. Moreover, by restricting the number of receptor genes competent for transcription at different times of development, temporal waves of expression may provide a mechanism for simplifying the regulation of the large odorant receptor gene family.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping