BIOGRAPHY AND RESEARCH INTERESTS
ZFIN ID: ZDB-PERS-970113-1
Olfaction presents an interesting and complex problem in perception: how does the olfactory apparatus of vertebrates detect and discriminate thousands of odors? Our approach to elucidating the mechanisms of olfactory discrimination involves the characterization of odorant receptors and the neural pathways that they activate. We are also interested in the developmental mechanisms responsible for specifying odorant receptor expression in olfactory neurons and the pathfinding of these cells' axons to their appropriate targets.
Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
Demaria, S., Berke, A.P., Van Name, E., Heravian, A., Ferreira, T., and Ngai, J. (2013) Role of a ubiquitously expressed receptor in the vertebrate olfactory system. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(38):15235-15247
French, C.R., Erickson, T., Callander, D., Berry, K.M., Koss, R., Hagey, D.W., Stout, J., Wuennenberg-Stapleton, K., Ngai, J., Moens, C.B., and Waskiewicz, A.J. (2007) Pbx homeodomain proteins pattern both the zebrafish retina and tectum. BMC Developmental Biology. 7(1):85
Brunet, L.J., G.H. Gold, and J. Ngai. 1996. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17, 681-693.
Speca, D.J., D.M. Lin, P.W. Sorensen, E.Y. Isacoff, J. Ngai, and A.H. Dittman. 1999. Functional identification of a goldfish odorant receptor. Neuron 23, 487-498.
Lin, D.M., F. Wang, G. Lowe, G. H. Gold, R. Axel, J. Ngai, and L. Brunet. 2000. Formation of precise synaptic connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron 26, 69-80.